Receptor glukagonu sličnog peptida 1

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Receptor glukagonu sličnog peptida 1‎‎

Prikaz bazira na PDB 3C59.
Dostupne strukture
3C59, 3C5T, 3IOL
Identifikatori
SimboliGLP1R; MGC138331
Vanjski IDOMIM138032 MGI99571 HomoloGene1558 IUPHAR: GLP-1 GeneCards: GLP1R Gene
Pregled RNK izražavanja
PBB GE GLP1R 208401 s at tn.png
PBB GE GLP1R 208390 s at tn.png
PBB GE GLP1R 208391 s at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez274014652
EnsemblENSG00000112164ENSMUSG00000024027
UniProtP43220E9Q7I1
RefSeq (mRNA)NM_002062.3NM_021332.2
RefSeq (protein)NP_002053.3NP_067307.2
Lokacija (UCSC)Chr 6:
39.02 - 39.06 Mb
Chr 17:
31.04 - 31.07 Mb
PubMed pretraga[1][2]

Receptor glukagonu sličnog peptida 1 (GLP1R) je ljudski gen koji se nalazi na hromozomu 6.[1][2] Ovaj protein je član glukogenske receptorske familije G protein spregnutih receptora.[3]

Specifičnost liganda[uredi - уреди | uredi izvor]

GLP1R specifično vezuje glukagonu sličan peptid-1 (GLP1) i ima mnogo manji afinitet za srodne peptide kao što su gastrični inhibitorni polipeptid i glukagon.[4]

Funkcija i terapeutski potencijal[uredi - уреди | uredi izvor]

GLP1R je izražen u pancreasnim beta ćelijama. Aktivirani GLP1R stimuliše adenilil ciklazni put što dovodi do povišene sinteze i otpuštanja insulina.[5] Consequently GLP1R has been suggested as a potential target for the treatment of dijabetes.[6]

GLP1R je isto tako izražen u mozgu gde učestvuje u kontroli apetita.[7] Miševi kod kojih je GLP1R izrađen u povećanoj meri pokazuju poboljšanu memoriju i sposobnost učenja.[8]

Reference[uredi - уреди | uredi izvor]

  1. Thorens B (September 1992). "Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1". Proc. Natl. Acad. Sci. U.S.A. 89 (18): 8641–5. PMC 49976. PMID 1326760. doi:10.1073/pnas.89.18.8641. 
  2. Dillon JS, Tanizawa Y, Wheeler MB, Leng XH, Ligon BB, Rabin DU, Yoo-Warren H, Permutt MA, Boyd AE 3rd (October 1993). "Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor". Endocrinology 133 (4): 1907–10. PMID 8404634. doi:10.1210/en.133.4.1907. 
  3. Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors" (PDF). Recept. Channels 8 (3-4): 179–88. PMID 12529935. doi:10.1080/10606820213687. Pristupljeno 2008-07-14. 
  4. Fehmann HC, Jiang J, Schweinfurth J, Dörsch K, Wheeler MB, Boyd AE 3rd, Göke B (April 1994). "Ligand-specificity of the rat GLP-I receptor recombinantly expressed in Chinese hamster ovary (CHO-) cells". Z Gastroenterol 32 (4): 203–7. PMID 8017094. 
  5. Drucker DJ, Philippe J, Mojsov S, Chick WL, Habener JF (May 1987). "Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3434–8. PMC 304885. PMID 3033647. doi:10.1073/pnas.84.10.3434. 
  6. Holst JJ (May 2004). "Treatment of type 2 diabetes mellitus with agonists of the GLP-1 receptor or DPP-IV inhibitors". Expert Opin Emerg Drugs 9 (1): 155–66. PMID 15155141. doi:10.1517/eoed.9.1.155.32952. 
  7. Kinzig KP, D'Alessio DA, Seeley RJ (2002-12-01). "The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness". J. Neurosci. 22 (23): 10470–6. PMID 12451146. 
  8. During MJ, Cao L, Zuzga DS, Francis JS, Fitzsimons HL, Jiao X, Bland RJ, Klugmann M, Banks WA, Drucker DJ, Haile CN (September 2003). "Glucagon-like peptide-1 receptor is involved in learning and neuroprotection". Nat. Med. 9 (9): 1173–9. PMID 12925848. doi:10.1038/nm919. 

Literatura[uredi - уреди | uredi izvor]

Vidi još[uredi - уреди | uredi izvor]

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