Prostaglandinski E2 receptor

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Prostaglandinski E receptor 2
Identifikatori
SimboliPTGER2; EP2
Vanjski IDOMIM176804 MGI97794 HomoloGene739 IUPHAR: EP2 GeneCards: PTGER2 Gene
Pregled RNK izražavanja
PBB GE PTGER2 206631 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez573219217
EnsemblENSG00000125384ENSMUSG00000037759
UniProtP43116Q62053
RefSeq (mRNA)NM_000956.3NM_008964.4
RefSeq (protein)NP_000947.2NP_032990.1
Lokacija (UCSC)Chr 14:
52.78 - 52.8 Mb
Chr 14:
45.61 - 45.62 Mb
PubMed pretraga[1][2]

Prostaglandinski E2 receptor (EP2) je prostaglandinski receptor za prostaglandin E2. On je kodiran ljudskim genom PTGER2.[1]

On je povezan sa aspirinom indukovanom astmom.[2]

Mehanizam[uredi - уреди | uredi izvor]

Ovaj protein je G protein spregnuti receptor, koji aktivira G protein Gs.[3]

Reference[uredi - уреди | uredi izvor]

Literatura[uredi - уреди | uredi izvor]

  • Duncan AM, Anderson LL, Funk CD et al. (1995). "Chromosomal localization of the human prostanoid receptor gene family.". Genomics 25 (3): 740–2. PMID 7759114. doi:10.1016/0888-7543(95)80022-E. 
  • Regan JW, Bailey TJ, Pepperl DJ et al. (1994). "Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype.". Mol. Pharmacol. 46 (2): 213–20. PMID 8078484. 
  • Bastien L, Sawyer N, Grygorczyk R et al. (1994). "Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype.". J. Biol. Chem. 269 (16): 11873–7. PMID 8163486. 
  • An S, Yang J, Xia M, Goetzl EJ (1994). "Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2.". Biochem. Biophys. Res. Commun. 197 (1): 263–70. PMID 8250933. doi:10.1006/bbrc.1993.2470. 
  • Stillman BA, Breyer MD, Breyer RM (1999). "Importance of the extracellular domain for prostaglandin EP(2) receptor function.". Mol. Pharmacol. 56 (3): 545–51. PMID 10462542. 
  • Smock SL, Pan LC, Castleberry TA et al. (1999). "Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E(2) receptor EP2 subtype.". Gene 237 (2): 393–402. PMID 10521663. doi:10.1016/S0378-1119(99)00323-6. 
  • Desai S, April H, Nwaneshiudu C, Ashby B (2001). "Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration.". Mol. Pharmacol. 58 (6): 1279–86. PMID 11093764. 
  • Duckworth N, Marshall K, Clayton JK (2002). "An investigation of the effect of the prostaglandin EP2 receptor agonist, butaprost, on the human isolated myometrium from pregnant and non-pregnant women.". J. Endocrinol. 172 (2): 263–9. PMID 11834444. doi:10.1677/joe.0.1720263. 
  • Kyveris A, Maruscak E, Senchyna M (2002). "Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR.". Mol. Vis. 8: 51–8. PMID 11951086. 
  • Takafuji VA, Evans A, Lynch KR, Roche JK (2003). "PGE(2) receptors and synthesis in human gastric mucosa: perturbation in cancer.". Prostaglandins Leukot. Essent. Fatty Acids 66 (1): 71–81. PMID 12051958. doi:10.1054/plef.2001.0299. 
  • Scandella E, Men Y, Gillessen S et al. (2002). "Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells.". Blood 100 (4): 1354–61. PMID 12149218. doi:10.1182/blood-2001-11-0017. 
  • Okuyama T, Ishihara S, Sato H et al. (2002). "Activation of prostaglandin E2-receptor EP2 and EP4 pathways induces growth inhibition in human gastric carcinoma cell lines.". J. Lab. Clin. Med. 140 (2): 92–102. PMID 12228765. 
  • Konger RL, Scott GA, Landt Y et al. (2003). "Loss of the EP2 prostaglandin E2 receptor in immortalized human keratinocytes results in increased invasiveness and decreased paxillin expression.". Am. J. Pathol. 161 (6): 2065–78. PMC 1850902. PMID 12466123. doi:10.1016/S0002-9440(10)64485-9. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Abulencia JP, Gaspard R, Healy ZR et al. (2003). "Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells". J. Biol. Chem. 278 (31): 28388–94. PMID 12743126. doi:10.1074/jbc.M301378200. 
  • Richards JA, Brueggemeier RW (2003). "Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes". J. Clin. Endocrinol. Metab. 88 (6): 2810–6. PMID 12788892. doi:10.1210/jc.2002-021475. 
  • Sun HS, Hsiao KY, Hsu CC et al. (2003). "Transactivation of steroidogenic acute regulatory protein in human endometriotic stromalcells is mediated by the prostaglandin EP2 receptor". Endocrinology 144 (9): 3934–42. PMID 12933667. doi:10.1210/en.2003-0289. 
  • Bradbury DA, Newton R, Zhu YM et al. (2004). "Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, E-prostanoid 2 (EP2), and EP4 receptors". J. Biol. Chem. 278 (50): 49954–64. PMID 14517215. doi:10.1074/jbc.M307964200. 
  • Moreland RB, Kim N, Nehra A et al. (2004). "Functional prostaglandin E (EP) receptors in human penile corpus cavernosum". Int. J. Impot. Res. 15 (5): 362–8. PMID 14562138. doi:10.1038/sj.ijir.3901042. 
  • Sugimoto Y, Nakato T, Kita A et al. (2004). "A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors". J. Biol. Chem. 279 (12): 11016–26. PMID 14699136. doi:10.1074/jbc.M307404200. 

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