F2RL2

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Proteazom-aktivirani receptor 3
Identifikatori
SimboliF2RL2; PAR3
Vanjski IDOMIM601919 MGI1298208 HomoloGene36151 IUPHAR: PAR3 GeneCards: F2RL2 Gene
Pregled RNK izražavanja
PBB GE F2RL2 206795 at tn.png
podaci
Ortolozi
VrstaČovekMiš
Entrez215114064
EnsemblENSG00000164220ENSMUSG00000021675
UniProtO00254Q3UXV3
RefSeq (mRNA)NM_004101NM_010170
RefSeq (protein)NP_004092NP_034300
Lokacija (UCSC)Chr 5:
75.95 - 75.95 Mb
Chr 13:
96.8 - 96.8 Mb
PubMed pretraga[1][2]

Proteazom-aktivirani receptor 3 (PAR3), ili Receptoru koagulacionog faktora II (trombina) sličan 2, je protein kodiran F2RL2 genom kod ljudi.

F2RL2 je član velike familije G-protein spregnutih receptora koji interaguju sa guanozin-nukleotid-vezujućim proteinima. PAR3 je takođe član familije proteazom aktiviranih receptora. On je aktiviran trombinom. Do aktivacije dolazi proteolitičkim odsecanjem njegovog ekstracelularnog amino terminusa. Novo-formirani amino terminus dejstvuje kao vezani ligand i aktivira receptor. F2RL2 je kofaktor za F2RL3 aktivaciju trombinom. On posreduje trombinom-podstaknutu fosfoinozitid hidrolizu. F2RL2 je izražen u nizu tkiva.[1]

Vidi još[uredi - уреди | uredi izvor]

Reference[uredi - уреди | uredi izvor]

Literatura[uredi - уреди | uredi izvor]

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