OPN3
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| edit |
| Opsin 3 (encefalopsin, panopsin) | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | OPN3; ECPN | ||||||||||
| Vanjski ID | OMIM: 606695 MGI: 1338022 HomoloGene: 40707 IUPHAR: OPN3 GeneCards: OPN3 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 23596 | 13603 | |||||||||
| Ensembl | ENSG00000054277 | ENSMUSG00000026525 | |||||||||
| UniProt | Q9H1Y3 | Q3KR48 | |||||||||
| RefSeq (mRNA) | NM_001030011 | NM_010098 | |||||||||
| RefSeq (protein) | NP_001025182 | NP_034228 | |||||||||
| Lokacija (UCSC) | Chr 1: 239.82 - 239.87 Mb | Chr 1: 177.5 - 177.53 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
OPN3, ili Opsin-3, je protein koji je kod čoveka kodiran OPN3 genom.[1][2][3] Alternativno splajsovanje ovog gena proizvodi više transkriptnih varijanti, koje kodiraju različite proteinske izoforme.
Funkcija[uredi | uredi kod]
Opsini su članovi familije G protein-spregnutih receptora. Osim vizuelnih opsina, sisari poseduje nekoliko fotoreceptivnih ne-vizuelnih opsina koji su izraženi u tkivima izvan oka. Gen opsina-3 je u znatnoj meri izražen u mozgu i testisima, a u maloj meri i u jetri, materici, srcu, plućima, skeletalnim mišima, bubrezima, i pankreasu. Ovaj gene isto tako može da bude izražen u mrežnjači. Ovaj protein poseduje kanoničke osobine fotoreceptivnih opsina.[3]
Literatura[uredi | uredi kod]
- ↑ Blackshaw S, Snyder SH (Jun 1999). „Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain”. J Neurosci 19 (10): 3681–90. PMID 10234000.
- ↑ Halford S, Freedman MS, Bellingham J, Inglis SL, Poopalasundaram S, Soni BG, Foster RG, Hunt DM (Jun 2001). „Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43”. Genomics 72 (2): 203–8. DOI:10.1006/geno.2001.6469. PMID 11401433.
- ↑ 3,0 3,1 „Entrez Gene: OPN3 opsin 3 (encephalopsin, panopsin)”.
Dodatna literatura[uredi | uredi kod]
- Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery.”. Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548.
- Halford S, Bellingham J, Ocaka L i dr.. (2002). „Assignment of panopsin (OPN3) to human chromosome band 1q43 by in situ hybridization and somatic cell hybrids.”. Cytogenet. Cell Genet. 95 (3-4): 234–5. DOI:10.1159/000059351. PMID 12063405.
- Kasper G, Taudien S, Staub E i dr.. (2003). „Different structural organization of the encephalopsin gene in man and mouse.”. Gene 295 (1): 27–32. DOI:10.1016/S0378-1119(02)00799-0. PMID 12242008.
- Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Alam NA, Gorman P, Jaeger EE i dr.. (2004). „Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability.”. Cancer Genet. Cytogenet. 147 (2): 121–7. DOI:10.1016/S0165-4608(03)00196-1. PMID 14623461.
- Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Gregory SG, Barlow KF, McLay KE i dr.. (2006). „The DNA sequence and biological annotation of human chromosome 1.”. Nature 441 (7091): 315–21. DOI:10.1038/nature04727. PMID 16710414.