Komponenta komplementa 3
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| edit |
| Komponenta komplementa 3 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB prikaz baziran na 1c3d. | |||||||||||
| Dostupne strukture | |||||||||||
| 1c3d, 1ghq, 1w2s, 2a73, 2a74, 2b39, 2gox, 2hr0, 2i07, 2ice, 2icf | |||||||||||
| Identifikatori | |||||||||||
| Simboli | C3; ASP; CPAMD1 | ||||||||||
| Vanjski ID | OMIM: 120700 MGI: 88227 HomoloGene: 68031 GeneCards: C3 Gene | ||||||||||
| |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 718 | 12266 | |||||||||
| Ensembl | ENSG00000125730 | ENSMUSG00000024164 | |||||||||
| UniProt | P01024 | Q207D2 | |||||||||
| RefSeq (mRNA) | NM_000064 | NM_009778 | |||||||||
| RefSeq (protein) | NP_000055 | NP_033908 | |||||||||
| Lokacija (UCSC) | Chr 19: 6.68 - 6.73 Mb | Chr 17: 56.89 - 56.91 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Komponenta komplementa 3 (C3) je protein imunskog sistema. On ima centralnu ulogu u sistemu komplementa i doprinosi urođenoj imunosti. Kod ljudi je on kodiran na hromozomu 19 C3 genom.[1][2]
Funkcija[uredi | uredi kod]
C3 ima centralnu mesto u aktivaciji sistema komplementa.[3] Njegova aktivacija je neophodna u putevima aktivacije klasičnog i alternativnnog komplementa. Ljudi sa C3 deficijencijom su podložni bakterijskim infekcijama.[4][5]
Struktura[uredi | uredi kod]
Nekoliko C3 kristalnih struktura je rešeno.[6] Ovaj protein se sastoji od 13 domena.[7][8][9][10]
Interakcije[uredi | uredi kod]
Za komponenta komplementa 3 je pokazano da interaguje sa faktorom H.[11][12]
Literatura[uredi | uredi kod]
- ↑ de Bruijn MH, Fey GH (February 1985). „Human complement component C3: cDNA coding sequence and derived primary structure”. Proc. Natl. Acad. Sci. U.S.A. 82 (3): 708–12. DOI:10.1073/pnas.82.3.708. PMC 397115. PMID 2579379.
- ↑ „Entrez Gene: C3 complement component 3”.
- ↑ Sahu A, Lambris JD (April 2001). „Structure and biology of complement protein C3, a connecting link between innate and acquired immunity”. Immunol. Rev. 180: 35–48. DOI:10.1034/j.1600-065X.2001.1800103.x. PMID 11414361.
- ↑ Lachmann P (December 1975). „Genetics of the complement system”. J. Med. Genet. 12 (4): 372–7. DOI:10.1136/jmg.12.4.372. PMC 1013316. PMID 768477.
- ↑ Matsuyama W, Nakagawa M, Takashima H, Muranaga F, Sano Y, Osame M (December 2001). „Molecular analysis of hereditary deficiency of the third component of complement (C3) in two sisters”. Intern. Med. 40 (12): 1254–8. DOI:10.2169/internalmedicine.40.1254. PMID 11813855.
- ↑ „Advanced search results for UniProt accession P01024”. Protein Data Bank in Europe (PDBe). European Bioinformatics Institute. Pristupljeno 27. 12. 2010.
- ↑ Janssen BJ, Huizinga EG, Raaijmakers HC, Roos A, Daha MR, Nilsson-Ekdahl K, Nilsson B, Gros P (September 2005). „Structures of complement component C3 provide insights into the function and evolution of immunity”. Nature 437 (7058): 505–11. DOI:10.1038/nature04005. PMID 16177781.
- ↑ Janssen BJ, Christodoulidou A, McCarthy A, Lambris JD, Gros P (November 2006). „Structure of C3b reveals conformational changes that underlie complement activity”. Nature 444 (7116): 213–6. DOI:10.1038/nature05172. PMID 17051160.
- ↑ Wiesmann C, Katschke KJ, Yin J, Helmy KY, Steffek M, Fairbrother WJ, McCallum SA, Embuscado L, DeForge L, Hass PE, van Lookeren Campagne M (November 2006). „Structure of C3b in complex with CRIg gives insights into regulation of complement activation”. Nature 444 (7116): 217–20. DOI:10.1038/nature05263. PMID 17051150.
- ↑ Fredslund F, Jenner L, Husted LB, Nyborg J, Andersen GR, Sottrup-Jensen L (August 2006). „The structure of bovine complement component 3 reveals the basis for thioester function”. J. Mol. Biol. 361 (1): 115–27. DOI:10.1016/j.jmb.2006.06.009. PMID 16831446.
- ↑ Soames, C J; Sim R B (September 1997). „Interactions between human complement components factor H, factor I and C3b”. Biochem. J. (ENGLAND) 326 ( Pt 2): 553–61. ISSN 0264-6021. PMC 1218704. PMID 9291131.
- ↑ Jokiranta, T S; Westin J, Nilsson U R, Nilsson B, Hellwage J, Löfås S, Gordon D L, Ekdahl K N, Meri S (March 2001). „Complement C3b interactions studied with surface plasmon resonance technique”. Int. Immunopharmacol. (Netherlands) 1 (3): 495–506. DOI:10.1016/S1567-5769(00)00042-4. ISSN 1567-5769. PMID 11367533.
Dodatna literatura[uredi | uredi kod]
- Bradley, D T; Zipfel, P F; Hughes, A E (2011). „Complement in age-related macular degeneration: a focus on function”. Eye. DOI:10.1038/eye.2011.37.