LY-272,015

LY-272,015
(IUPAC) ime
	1-(3,4-dimetoksibenzil)-6-metil-2,3,4,9-tetrahidro-1H-β-karbolin
Klinički podaci
Identifikatori
CAS broj	172895-15-7
ATC kod	nije dodeljen
PubChem	9929424
Hemijski podaci
Formula	C21H24N2O2
Mol. masa	336,426 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C21H24N2O2/c1-13-4-6-17-16(10-13)15-8-9-22-18(21(15)23-17)11-14-5-7-19(24-2)20(12-14)25-3/h4-7,10,12,18,22-23H,8-9,11H2,1-3H3 ; Key: GDAJGLDMCDMPIR-UHFFFAOYSA-N
Sinonimi	LY-272,015; 1-[(3,4-Dimetoksifenil)metil]-2,3,4,9-tetrahidro-6-metil-1H-pirido[3,4-b]indol
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

LY-272,015 je derivat beta-karbolina. Ovaj lek je razvila kompanija Eli Lili. On deluje kao potentan i selektivan antagonist serotoninskog 5-HT_2B receptora. On pokazuje antihipertenzivna svojstva u životinjskim modelima,^[3]^[4] a takođe se koristi u istraživanjima drugih funkcija 5-HT_2B receptora.^[5]

Literatura[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Watts SW, Fink GD. 5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats. American Journal of Physiology. 1999 Mar;276(3 Pt 2):H944-52. PMID 10070078
↑ Russell A, Banes A, Berlin H, Fink GD, Watts SW. 5-Hydroxytryptamine(2B) receptor function is enhanced in the N(omega)-nitro-L-arginine hypertensive rat. Journal of Pharmacology and Experimental Therapeutics. 2002 Oct;303(1):179-87. PMID 12235249
↑ Günther S, Maroteaux L, Schwarzacher SW. Endogenous 5-HT2B receptor activation regulates neonatal respiratory activity in vitro. Journal of Neurobiology. 2006 Aug;66(9):949-61. DOI:10.1002/neu.20253 PMID 16758492

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