Aceglutamid
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Aceglutamid | |||
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IUPAC ime |
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Drugi nazivi | α-N-Acetilglutamin | ||
Identifikacija | |||
CAS registarski broj | 2490-97-3 S | ||
PubChem[1][2] | 25561, 444019 R, 182230 S | ||
ChemSpider[3] | 23836 , 392045 R , 158492 S | ||
UNII | 01J18G9G97 | ||
EINECS broj | |||
DrugBank | DB04167 | ||
KEGG[4] | |||
MeSH | |||
Jmol-3D slike | Slika 1 Slika 2 | ||
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Svojstva | |||
Molekulska formula | C7H12N2O4 | ||
Molarna masa | 188.18 g mol−1 | ||
Agregatno stanje | Beli kristali | ||
Tačka topljenja |
197 °C, 470 K, 387 °F | ||
Srodna jedinjenja | |||
Srodna alkanoinske kiseline | |||
Srodna jedinjenja | |||
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Infobox references |
Aceglutamid je psihostimulans i nutropik[5] koji se koristi za poboljšanje memorije i koncentracije.[6] Hemijski, on je acetilni derivat aminokiseline L-glutamina.
So aceglutamid aluminijum (KW-110, ili Glumal) je efektivna u tretmanu čireva.[7][8][9][10]
Aceglutamid se takođe može koristiti kao izvor glutamina koji je stabilian u tečnom stanju.[11][12][13]
Reference[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Susan Budavari, ur. (2001). The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (13th izd.). Merck Publishing. ISBN 0-911910-13-1.
- ↑ Macdonald, F, ur. (1997). Dictionary of pharmacological agents. str. A-00018. ISBN 978-0-412-46630-4.
- ↑ Ito, M; Yokochi, E; Kobayashi, C; Suzuki, Y (1982). „Studies on defensive factors of experimental ulcers (2). Increasing action of aceglutamide aluminum on defensive factors in acetic acid ulcers of rats (author's transl)”. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 79 (4): 327–34. PMID 7095654.
- ↑ Harada, Masatoshi; Yano, Shingo (1974). „Inhibitory effect of N-acetyl-L-glutamine aluminum complex (KW-110) and related compounds on gastric erosion and motility in stressed animals”. Oyo Yakuri 8 (1): 1–6.
- ↑ Varas Lorenzo, MJ; López Martínez, A; Gordillo Bernal, J; Mundet Surroca, J (1991). „Comparative study of 3 drugs (aceglutamide aluminum, zinc acexamate, and magaldrate) in the long-term maintenance treatment (1 year) of peptic ulcer”. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 80 (2): 91–4. PMID 1790087.
- ↑ Tanaka, H; Shuto, K; Marumo, H (1982). „Effect of N-acetyl-L-glutamine aluminum complex (KW-110), an antiulcer agent, on the non-steroidal anti-inflammatory drug-induced exacerbation of gastric ulcer in rats”. Japanese journal of pharmacology 32 (2): 307–13. PMID 7098147.
- ↑ Lopez-Pedrosa Jose M; Manzano Manuel; Baxter Jeffrey H; Rueda Ricardo (2007). „N-acetyl-L-glutamine, a liquid-stable source of glutamine, partially prevents changes in body weight and on intestinal immunity induced by protein energy malnutrition in pigs”. Digestive diseases and sciences 52 (3): 650–658. DOI:10.1007/s10620-006-9500-y. PMID 17253138.
- ↑ JP 10101576
- ↑ US 2003099722
Литература[uredi | uredi kod]
- Macdonald, F, ur. (1997). Dictionary of pharmacological agents. str. A-00018. ISBN 978-0-412-46630-4.