Otvarač kalijumskog kanala

Iz Wikipedije, slobodne enciklopedije
(Preusmjereno sa Otvarač kalijum kanala)
Idi na navigaciju Idi na pretragu

Otvarač kalijum kanala je tip leka koji posreduje jonsku transmisiju kroz kalijumske kanale.

Primeri lekova iz ove grupe su:

  • Diazoksid[1] vazodilatator koji se koristi za tretman hipertenzije, i relaksaciju glatkih mišića
  • Minoksidil[2] vazodilator koji se koristi za hipertenziju, kao i za sprečavanje gubitka kose
  • Nikorandil[3] vazodilator koji se koristi za tretman angine
  • Pinacidil[4]
  • Retigabin,[5][6] antikonvulsant
  • Flupirtin, analgetik sa svojstvima mišićnog relaksanta i antikonvulsanta

Reference[uredi - уреди | uredi izvor]

  1. Mizutani S, Prasad SM, Sellitto AD, Schuessler RB, Damiano RJ, Lawton JS (August 2005). "Myocyte volume and function in response to osmotic stress: observations in the presence of an adenosine triphosphate-sensitive potassium channel opener". Circulation 112 (9 Suppl): I219–23. PMID 16159820. doi:10.1161/CIRCULATIONAHA.104.523746. 
  2. Wang T (February 2003). "The effects of the potassium channel opener minoxidil on renal electrolytes transport in the loop of henle". J. Pharmacol. Exp. Ther. 304 (2): 833–40. PMID 12538840. doi:10.1124/jpet.102.043380. 
  3. Sudo H, Yogo K, Ishizuka N, Otsuka H, Horie S, Saito K (November 2008). "Nicorandil, a potassium channel opener and nitric oxide donor, improves the frequent urination without changing the blood pressure in rats with partial bladder outlet obstruction". Biol. Pharm. Bull. 31 (11): 2079–82. PMID 18981577. doi:10.1248/bpb.31.2079. 
  4. Stojnic N, Gojkovic-Bukarica L, Peric M et al. (June 2007). "Potassium channel opener pinacidil induces relaxation of the isolated human radial artery". J. Pharmacol. Sci. 104 (2): 122–9. PMID 17538231. doi:10.1254/jphs.FP0061434. 
  5. Rundfeldt C (October 1997). "The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells". European Journal of Pharmacology 336 (2–3): 243–9. PMID 9384239. doi:10.1016/S0014-2999(97)01249-1. 
  6. Main MJ, Cryan JE, Dupere JR, Cox B, Clare JJ, Burbidge SA (August 2000). "Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine". Molecular Pharmacology 58 (2): 253–62. PMID 10908292. 

Vidi još[uredi - уреди | uredi izvor]