Karoksazon

Karoksazon
(IUPAC) ime
	2-(2-okso-4H-1,3-benzoksazin-3-il)acetamid
Klinički podaci
Identifikatori
CAS broj	18464-39-6
ATC kod	nije dodeljen
PubChem	29083
ChemSpider	27057
UNII	807N226MNL
Hemijski podaci
Formula	C10H10N2O3
Mol. masa	206,20 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C10H10N2O3/c11-9(13)6-12-5-7-3-1-2-4-8(7)15-10(12)14/h1-4H,5-6H2,(H2,11,13) ; Key: KYCBWEZLKCTALM-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	℞ Prescription only
Način primene	Oralno

Karoksazon (Surodil, Timostenil) je antidepresiv koji se nekad koristio za tretman depresije ali više nije u prodaji.^[4]^[5] On deluje kao reverzibilni inhibitor monoaminske oksidaze (MAOI) oba podtipa: MAO-A i MAO-B, sa pet puta većom potentnošću na MAO-B.^[6]^[7]^[8]^[9]^[10]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
↑ Cecchini S, Petri P, Ardito R, Bareggi SR, Torriti A (1978). „A comparative double-blind trial of the new antidepressant caroxazone and amitriptyline”. The Journal of International Medical Research 6 (5): 388–94. PMID 359383.
↑ Lieberman, A. N. (1994). Monoamine oxidase inhibitors in neurological diseases. New York: M. Dekker. ISBN 0-8247-9082-0.
↑ Moretti A, Caccia C, Martini A, et al. (May 1981). „Effect of caroxazone, a new antidepressant drug, on monoamine oxidases in healthy volunteers”. British Journal of Clinical Pharmacology 11 (5): 511–5. PMC 1401585. PMID 7272163.
↑ Moretti A, Caccia C, Calderini G, Menozzi M, Amico A (October 1981). „Studies on the mechanism of action of caroxazone, a new antidepressant drug”. Biochemical Pharmacology 30 (19): 2728–31. DOI:10.1016/0006-2952(81)90549-9. PMID 6170295.
↑ Martini A, Bonollo L, Nicolis FB, Sega R, Palermo A (June 1981). „Effects of caroxazone, a reversible monoamine oxidase inhibitor, on the pressor response to oral tyramine in man”. British Journal of Clinical Pharmacology 11 (6): 611–5. PMC 1402186. PMID 7272178.
↑ Martini A, Bonollo L, Nicolis FB, Sega R, Palermo A, Braibanti E (June 1981). „Effects of caroxazone, a reversible monoamine oxidase inhibitor, on the pressor response to intravenous tyramine in man”. British Journal of Clinical Pharmacology 11 (6): 605–10. PMC 1402193. PMID 7272177.

Literatura

Lieberman, A. N. (1994). Monoamine oxidase inhibitors in neurological diseases. New York: M. Dekker. ISBN 0-8247-9082-0.
Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.

Povezano

Paraksazon

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[isbn0-412-54090-8-4] Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.

[pmid359383-5] Cecchini S, Petri P, Ardito R, Bareggi SR, Torriti A (1978). „A comparative double-blind trial of the new antidepressant caroxazone and amitriptyline”. The Journal of International Medical Research 6 (5): 388–94. PMID 359383.

[isbn0-8247-9082-0-6] Lieberman, A. N. (1994). Monoamine oxidase inhibitors in neurological diseases. New York: M. Dekker. ISBN 0-8247-9082-0.

[pmid7272163-7] Moretti A, Caccia C, Martini A, et al. (May 1981). „Effect of caroxazone, a new antidepressant drug, on monoamine oxidases in healthy volunteers”. British Journal of Clinical Pharmacology 11 (5): 511–5. PMC 1401585. PMID 7272163.

[pmid6170295-8] Moretti A, Caccia C, Calderini G, Menozzi M, Amico A (October 1981). „Studies on the mechanism of action of caroxazone, a new antidepressant drug”. Biochemical Pharmacology 30 (19): 2728–31. DOI:10.1016/0006-2952(81)90549-9. PMID 6170295.

[pmid7272178-9] Martini A, Bonollo L, Nicolis FB, Sega R, Palermo A (June 1981). „Effects of caroxazone, a reversible monoamine oxidase inhibitor, on the pressor response to oral tyramine in man”. British Journal of Clinical Pharmacology 11 (6): 611–5. PMC 1402186. PMID 7272178.

[pmid7272177-10] Martini A, Bonollo L, Nicolis FB, Sega R, Palermo A, Braibanti E (June 1981). „Effects of caroxazone, a reversible monoamine oxidase inhibitor, on the pressor response to intravenous tyramine in man”. British Journal of Clinical Pharmacology 11 (6): 605–10. PMC 1402193. PMID 7272177.

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