5-MeO-NBpBrT
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| |||
| (IUPAC) ime | |||
|---|---|---|---|
| N-(4-Bromobenzil)-2-(5-metoksi-1H-indol-3-il)etanamin | |||
| Klinički podaci | |||
| Identifikatori | |||
| ATC kod | nije dodeljen | ||
| PubChem[1][2] | 5124753 | ||
| ChemSpider[3] | 4299315 | ||
| ChEMBL[4] | CHEMBL57427 
| ||
| Hemijski podaci | |||
| Formula | C18H19BrN2O | ||
| Mol. masa | 359,260 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
5-MeO-NBpBrT (5-Metoksi-N-(4-bromobenzil)triptamin) je lek koji deluje kao antagonist za 5-HT2A receptor,[5] koji je sto puta selektivniji za taj receptor u odnosu na blisko srodni 5-HT2C receptor.[6][7][8]
Reference[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Niels Jensen. Tryptamines as Ligands and Modulators of the Serotonin 5-HT2A Receptor and the Isolation of Aeruginascin from the Hallucinogenic Mushroom Inocybe aeruginascens. PhD dissertation, Georg-August-Universität zu Göttingen, 2004.
- ↑ Glennon RA, Dukat M, el-Bermawy M, Law H, De los Angeles J, Teitler M, King A, Herrick-Davis K. Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines. Journal of Medicinal Chemistry. 1994 Jun 24;37(13):1929-35. PMID 8027974
- ↑ Maria Silva PhD. Theoretical study of the interaction of agonists with the 5-HT2A receptor. Universität Regensburg, 2009.
- ↑ Silva ME, Heim R, Strasser A, Elz S, Dove S (January 2011). „Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor”. Journal of Computer-aided Molecular Design 25 (1): 51–66. DOI:10.1007/s10822-010-9400-2. PMID 21088982.