VER-3323

VER-3323
(IUPAC) ime
	(2S)-1-(6-bromo-2,3-dihidroindol-1-il)propan-2-amin
Klinički podaci
Identifikatori
ATC kod	?
PubChem	6604042
Hemijski podaci
Formula	C11H15BrN2
Mol. masa	255,154 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C11H15BrN2/c1-8(13)7-14-5-4-9-2-3-10(12)6-11(9)14/h2-3,6,8H,4-5,7,13H2,1H3 ; Key: QGRQJMXAQYGAKK-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

VER-3323 je lek koji deluje kao selektivni agonist 5-HT_2B i 5-HT_2C serotoninskih receptora, sa umerenom selektivnošću za 5-HT_2C, i relativno niskim afinitetom za 5-HT_2A. U životinjskim studijama je utvrđeno da je on potentan anoreksik .^[3]^[4]^[5]^[6]

Vidi još[uredi | uredi kod]

Literatura[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M (August 2004). „Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors”. Naunyn-Schmiedeberg's Archives of Pharmacology 370 (2): 114–23. DOI:10.1007/s00210-004-0951-4. PMID 15322733.
↑ Halford JC, Harrold JA, Lawton CL, Blundell JE (March 2005). „Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity”. Current Drug Targets 6 (2): 201–13. PMID 15777190.
↑ Schuhler S, Clark A, Joseph W, Patel A, Lehnen K, Stratford E, Horan TL, Fone KC, Ebling FJ (May 2005). „Involvement of 5-HT receptors in the regulation of food intake in Siberian hamsters”. Journal of Neuroendocrinology 17 (5): 276–85. DOI:10.1111/j.1365-2826.2005.01303.x. PMID 15869562.
↑ Song J, Hanniford D, Doucette C, Graham E, Poole MF, Ting A, Sherf B, Harrington J, Brunden K, Stricker-Krongrad A (December 2005). „Development of homogeneous high-affinity agonist binding assays for 5-HT2 receptor subtypes”. Assay and Drug Development Technologies 3 (6): 649–59. DOI:10.1089/adt.2005.3.649. PMID 16438660.

Spoljašnje veze[uredi | uredi kod]

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[pmid15322733-3] Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M (August 2004). „Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors”. Naunyn-Schmiedeberg's Archives of Pharmacology 370 (2): 114–23. DOI:10.1007/s00210-004-0951-4. PMID 15322733.

[pmid15777190-4] Halford JC, Harrold JA, Lawton CL, Blundell JE (March 2005). „Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity”. Current Drug Targets 6 (2): 201–13. PMID 15777190.

[pmid15869562-5] Schuhler S, Clark A, Joseph W, Patel A, Lehnen K, Stratford E, Horan TL, Fone KC, Ebling FJ (May 2005). „Involvement of 5-HT receptors in the regulation of food intake in Siberian hamsters”. Journal of Neuroendocrinology 17 (5): 276–85. DOI:10.1111/j.1365-2826.2005.01303.x. PMID 15869562.

[pmid16438660-6] Song J, Hanniford D, Doucette C, Graham E, Poole MF, Ting A, Sherf B, Harrington J, Brunden K, Stricker-Krongrad A (December 2005). „Development of homogeneous high-affinity agonist binding assays for 5-HT2 receptor subtypes”. Assay and Drug Development Technologies 3 (6): 649–59. DOI:10.1089/adt.2005.3.649. PMID 16438660.

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VER-3323

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