S1PR4
(Preusmjereno sa stranice LPC1)
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| Sfingozin 1-fosfat receptor 4 | |||||||||||
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| Dostupne strukture | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | S1PR4; EDG6; LPC1; S1P4; SLP4 | ||||||||||
| Vanjski ID | OMIM: 603751 MGI: 1333809 HomoloGene: 2799 IUPHAR: S1P4 GeneCards: S1PR4 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 8698 | 13611 | |||||||||
| Ensembl | ENSG00000125910 | ENSMUSG00000044199 | |||||||||
| UniProt | O95977 | Q9Z0L1 | |||||||||
| RefSeq (mRNA) | NM_003775.3 | NM_010102.2 | |||||||||
| RefSeq (protein) | NP_003766.1 | NP_034232.1 | |||||||||
| Lokacija (UCSC) | Chr 19: 3.18 - 3.18 Mb | Chr 10: 80.96 - 80.96 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Sfingozin 1-fosfatni receptor 4 (S1PR4) je ljudski gen koji kodira G protein spregnuti receptor za koji se vezuje lipidni signalni molekul sfingozin 1-fosfat (S1P).[1] Gen S1PR4 ne sadrži introne.
Funkcija[uredi | uredi kod]
Ovaj protein učestvuje u endotelnoj diferencijaciji. Za njega se vezuju lizofosfolipidi ili lizosfingolipidi. On učestvuje u ćelijskoj signalizaciji mnogih ćelijskih tipova. Specifičan ze za limfoidna tkiva.[1]
Reference[uredi | uredi kod]
Literatura[uredi | uredi kod]
- Gräler MH, Bernhardt G, Lipp M (1998). „EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue.”. Genomics 53 (2): 164–9. DOI:10.1006/geno.1998.5491. PMID 9790765.
- Yamazaki Y, Kon J, Sato K, et al. (2000). „Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway.”. Biochem. Biophys. Res. Commun. 268 (2): 583–9. DOI:10.1006/bbrc.2000.2162. PMID 10679247.
- Van Brocklyn JR, Gräler MH, Bernhardt G, et al. (2000). „Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6.”. Blood 95 (8): 2624–9. PMID 10753843.
- Idzko M, Panther E, Corinti S, et al. (2002). „Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses.”. Faseb J. 16 (6): 625–7. PMID 11919175.
- Kveberg L, Bryceson Y, Inngjerdingen M, et al. (2002). „Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases.”. Eur. J. Immunol. 32 (7): 1856–64. DOI:10.1002/1521-4141(200207)32:7<1856::AID-IMMU1856>3.0.CO;2-B. PMID 12115604.
- Candelore MR, Wright MJ, Tota LM, et al. (2002). „Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor.”. Biochem. Biophys. Res. Commun. 297 (3): 600–6. DOI:10.1016/S0006-291X(02)02237-4. PMID 12270137.
- Contos JJ, Ye X, Sah VP, Chun J (2002). „Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene.”. FEBS Lett. 531 (1): 99–102. DOI:10.1016/S0014-5793(02)03409-9. PMID 12401211.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Vogler R, Sauer B, Kim DS, et al. (2003). „Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.”. J. Invest. Dermatol. 120 (4): 693–700. DOI:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.
- Gräler MH, Grosse R, Kusch A, et al. (2003). „The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13.”. J. Cell. Biochem. 89 (3): 507–19. DOI:10.1002/jcb.10537. PMID 12761884.
- Kyi CS, Key SJ, Lloyd TW (2003). „Use of a nasogastric catheter to prevent soft tissue entanglement of the externally ported distractor arm.”. International journal of oral and maxillofacial surgery 32 (3): 337–8. DOI:10.1054/ijom.2003.0364. PMID 12767884.
- Holdsworth G, Osborne DA, Pham TT, et al. (2005). „A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor.”. BMC Biochem. 5: 12. DOI:10.1186/1471-2091-5-12. PMID 15298705.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network.”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
Spoljašnje veze[uredi | uredi kod]
- „Lysophospholipid Receptors: S1P4”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
- MeSH Lysophospholipid+receptors