GABBR2
(Preusmjereno sa stranice HRIHFB2099)
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| Receptor 2 gama-aminobuterne kiseline B | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | GABBR2; GABABR2; GPR51; GPRC3B; HG20; HRIHFB2099 | ||||||||||
| Vanjski ID | OMIM: 607340 MGI: 2386030 HomoloGene: 55902 IUPHAR: GABAB2 GeneCards: GABBR2 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| Vrsta | Čovek | Miš | |||||||||
| Entrez | 9568 | 242425 | |||||||||
| Ensembl | ENSG00000136928 | ENSMUSG00000039809 | |||||||||
| UniProt | O75899 | Q80T41 | |||||||||
| RefSeq (mRNA) | NM_005458.7 | NM_001081141.1 | |||||||||
| RefSeq (protein) | NP_005449.5 | NP_001074610.1 | |||||||||
| Lokacija (UCSC) | Chr 9: 101.05 - 101.47 Mb | Chr 4: 46.68 - 47 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Receptor 2 gama-aminobuterne kiseline B (GABAB1) je podjedinica G protein spregnutog receptora koja je kod ljudi kodirana GABBR2 genom.[1]
B-tip receptora za neurotransmiter GABA (gama-aminobuterna kiselina) inhibira neuronsku aktivnost putem G protein spregnutog sistema sekundarnih glasnika, koji reguliše oslobađanje neurotransmiter, aktivnost jonskih kanala i adenilil ciklaze.[1]
Interakcije[uredi | uredi kod]
Poznato je da GABBR2 formira interakcije sa GABBR1.[2]
Reference[uredi | uredi kod]
- ↑ 1,0 1,1 „Entrez Gene: GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2”.
- ↑ White, J H; Wise A, Main M J, Green A, Fraser N J, Disney G H, Barnes A A, Emson P, Foord S M, Marshall F H (December 1998). „Heterodimerization is required for the formation of a functional GABA(B) receptor”. Nature (ENGLAND) 396 (6712): 679–82. DOI:10.1038/25354. ISSN 0028-0836. PMID 9872307.
Literatura[uredi | uredi kod]
- White JH, Wise A, Main MJ i dr.. (1999). „Heterodimerization is required for the formation of a functional GABA(B) receptor”. Nature 396 (6712): 679–82. DOI:10.1038/25354. PMID 9872316.
- Ng GY, Clark J, Coulombe N i dr.. (1999). „Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity”. J. Biol. Chem. 274 (12): 7607–10. DOI:10.1074/jbc.274.12.7607. PMID 10075644.
- Ng GY, McDonald T, Bonnert T i dr.. (1999). „Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9”. Genomics 56 (3): 288–95. DOI:10.1006/geno.1998.5706. PMID 10087195.
- Martin SC, Russek SJ, Farb DH (1999). „Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1”. Mol. Cell. Neurosci. 13 (3): 180–91. DOI:10.1006/mcne.1999.0741. PMID 10328880.
- Clark JA, Mezey E, Lam AS, Bonner TI (2000). „Distribution of the GABA(B) receptor subunit gb2 in rat CNS”. Brain Res. 860 (1–2): 41–52. DOI:10.1016/S0006-8993(00)01958-2. PMID 10727622.
- Sullivan R, Chateauneuf A, Coulombe N i dr.. (2000). „Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor”. J. Pharmacol. Exp. Ther. 293 (2): 460–7. PMID 10773016.
- White JH, McIllhinney RA, Wise A i dr.. (2001). „The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx”. Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967–72. DOI:10.1073/pnas.240452197. PMC 17684. PMID 11087824.
- Kitano J, Kimura K, Yamazaki Y i dr.. (2002). „Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins”. J. Neurosci. 22 (4): 1280–9. PMID 11850456.
- Salim K, Fenton T, Bacha J i dr.. (2002). „Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation”. J. Biol. Chem. 277 (18): 15482–5. DOI:10.1074/jbc.M201539200. PMID 11854302.
- Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Furtinger S, Pirker S, Czech T i dr.. (2004). „Increased expression of gamma-aminobutyric acid type B receptors in the hippocampus of patients with temporal lobe epilepsy”. Neurosci. Lett. 352 (2): 141–5. DOI:10.1016/j.neulet.2003.08.046. PMID 14625043.
- Waldvogel HJ, Billinton A, White JH i dr.. (2004). „Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia: immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor, and the GABABR1 and GABABR2 receptor subunits”. J. Comp. Neurol. 470 (4): 339–56. DOI:10.1002/cne.20005. PMID 14961561.
- Balasubramanian S, Teissére JA, Raju DV, Hall RA (2004). „Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking”. J. Biol. Chem. 279 (18): 18840–50. DOI:10.1074/jbc.M313470200. PMID 14966130.
- Uezono Y, Kaibara M, Hayashi H i dr.. (2004). „Characterization of GABAB receptor in the human colon”. J. Pharmacol. Sci. 94 (2): 211–3. DOI:10.1254/jphs.94.211. PMID 14978362.
- Humphray SJ, Oliver K, Hunt AR i dr.. (2004). „DNA sequence and analysis of human chromosome 9”. Nature 429 (6990): 369–74. DOI:10.1038/nature02465. PMC 2734081. PMID 15164053.
- Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hlavackova V, Goudet C, Kniazeff J i dr.. (2005). „Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR”. EMBO J. 24 (3): 499–509. DOI:10.1038/sj.emboj.7600557. PMC 548662. PMID 15660124.
- DeGiorgis JA, Jaffe H, Moreira JE i dr.. (2005). „Phosphoproteomic analysis of synaptosomes from human cerebral cortex”. J. Proteome Res. 4 (2): 306–15. DOI:10.1021/pr0498436. PMID 15822905.
- Rual JF, Venkatesan K, Hao T i dr.. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
- Osawa Y, Xu D, Sternberg D i dr.. (2006). „Functional expression of the GABAB receptor in human airway smooth muscle”. Am. J. Physiol. Lung Cell Mol. Physiol. 291 (5): L923–31. DOI:10.1152/ajplung.00185.2006. PMID 16829628.
Vidi još[uredi | uredi kod]
Spoljašnje veze[uredi | uredi kod]
- „GABAB Receptors: GABAB2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2014-08-08.