Metabotropni glutamatni receptor 6
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| Metabotropni glutamatni receptor 6 | |||
|---|---|---|---|
| Identifikatori | |||
| Simboli | GRM6; CSNB1B; GPRC1F; MGLUR6; mGlu6 | ||
| Vanjski ID | OMIM: 604096 HomoloGene: 20232 IUPHAR: mGlu6 GeneCards: GRM6 Gene | ||
| Pregled RNK izražavanja | |||
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| podaci | |||
| Ortolozi | |||
| Vrsta | Čovek | Miš | |
| Entrez | 2916 | n/a | |
| Ensembl | ENSG00000113262 | n/a | |
| UniProt | O15303 | n/a | |
| RefSeq (mRNA) | NM_000843.3 | n/a | |
| RefSeq (protein) | NP_000834.2 | n/a | |
| Lokacija (UCSC) | Chr 5: 178.39 - 178.42 Mb | n/a | |
| PubMed pretraga | [1] | n/a | |
Metabotropni glutamatni recepto 6 (GRM6) je protein koji je kod ljudi kodiran GRM6 genom.[1][2]
Funkcija[uredi | uredi kod]
L-glutamat je jedan od glavnih ekscitatornih neurotransmitera u centralnom nervnom sistemu. On aktivira jonotropne i metabotropne glutamatne receptore. Glutamatergična neurotransmisija učestvuje u većini aspekata normalih moždanih funkcija i njena perturbacija se javlja kod mnogih neuropatoloških obloljenja. Metabotropni glutamatni receptori su familija G protein spregnutih receptora, koja se deli u tri grupe na osnovu homologije sekvenci, mehanizama prenosa signala, i farmakoloških svojstava. Grupa I obuhvata GRM1 i GRM5. Ti receptori aktiviraju fosfolipazu C. Grupa II obuhvata GRM2 i GRM3, dok grupa III obuhvata GRM4, GRM6, GRM7 i GRM8. Receptori grupe II i III su povezani inhibicijom kaskade cikličnog AMP-a ali se razlikuju u njihovim selektivnostima za agoniste.[1]
Reference[uredi | uredi kod]
- ↑ 1,0 1,1 „Entrez Gene: GRM6 glutamate receptor, metabotropic 6”.
- ↑ Hashimoto T, Inazawa J, Okamoto N, Tagawa Y, Bessho Y, Honda Y, Nakanishi S (June 1997). „The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6”. Eur. J. Neurosci. 9 (6): 1226–35. DOI:10.1111/j.1460-9568.1997.tb01477.x. PMID 9215706.
Literatura[uredi | uredi kod]
- Hashimoto T, Inazawa J, Okamoto N, et al. (1997). „The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6”. Eur. J. Neurosci. 9 (6): 1226–35. DOI:10.1111/j.1460-9568.1997.tb01477.x. PMID 9215706.
- Dhingra A, Lyubarsky A, Jiang M, et al. (2001). „The light response of ON bipolar neurons requires G[alpha]o”. J. Neurosci. 20 (24): 9053–8. PMID 11124982.
- Valerio A, Ferraboli S, Paterlini M, et al. (2001). „Identification of novel alternatively-spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human retina”. Gene 262 (1–2): 99–106. DOI:10.1016/S0378-1119(00)00547-3. PMID 11179672.
- Dryja TP, McGee TL, Berson EL, et al. (2005). „Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6”. Proc. Natl. Acad. Sci. U.S.A. 102 (13): 4884–9. DOI:10.1073/pnas.0501233102. PMC 555731. PMID 15781871.
- Zeitz C, van Genderen M, Neidhardt J, et al. (2005). „Mutations in GRM6 cause autosomal recessive congenital stationary night blindness with a distinctive scotopic 15-Hz flicker electroretinogram”. Invest. Ophthalmol. Vis. Sci. 46 (11): 4328–35. DOI:10.1167/iovs.05-0526. PMID 16249515.
- Zeitz C, Forster U, Neidhardt J, et al. (2007). „Night blindness-associated mutations in the ligand-binding, cysteine-rich, and intracellular domains of the metabotropic glutamate receptor 6 abolish protein trafficking”. Hum. Mutat. 28 (8): 771–80. DOI:10.1002/humu.20499. PMID 17405131.
Vidi još[uredi | uredi kod]
Spoljašnje veze[uredi | uredi kod]
- „Metabotropic Glutamate Receptors: mGlu6”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-04.