CP-226,269

CP-226,269
(IUPAC) ime
	5-fluoro-2-[(4-piridin-2-ilpiperazin-1-il)metil]-1H-indol
Klinički podaci
Identifikatori
CAS broj	220941-93-5
ATC kod	nije dodeljen
PubChem	9796720
ChemSpider	7972486
ChEMBL	CHEMBL77395
Hemijski podaci
Formula	C18H19FN4
Mol. masa	310,368 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C18H19FN4/c19-15-4-5-17-14(11-15)12-16(21-17)13-22-7-9-23(10-8-22)18-3-1-2-6-20-18/h1-6,11-12,21H,7-10,13H2 ; Key: PQOIDBZLMJMYCD-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

CP-226,269 je lek koji deluje kao dopaminski agonist. On je selektivan za D₄ podtip. CP-226,269 se koristi za istraživanje uloge D4 receptora u mozgu.^[5]^[6]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Sharma A, Kramer ML, Wick PF, Liu D, Chari S, Shim S, Tan W, Ouellette D, Nagata M, DuRand CJ, Kotb M, Deth RC (May 1999). „D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia”. Molecular Psychiatry 4 (3): 235–46. DOI:10.1038/sj.mp.4000522. PMID 10395213.
↑ Basso AM, Gallagher KB, Bratcher NA, Brioni JD, Moreland RB, Hsieh GC, Drescher K, Fox GB, Decker MW, Rueter LE (July 2005). „Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test”. Neuropsychopharmacology 30 (7): 1257–68. DOI:10.1038/sj.npp.1300677. PMID 15688083.

Spoljašnje veze[uredi | uredi kod]

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid10395213-5] Sharma A, Kramer ML, Wick PF, Liu D, Chari S, Shim S, Tan W, Ouellette D, Nagata M, DuRand CJ, Kotb M, Deth RC (May 1999). „D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia”. Molecular Psychiatry 4 (3): 235–46. DOI:10.1038/sj.mp.4000522. PMID 10395213.

[pmid15688083-6] Basso AM, Gallagher KB, Bratcher NA, Brioni JD, Moreland RB, Hsieh GC, Drescher K, Fox GB, Decker MW, Rueter LE (July 2005). „Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test”. Neuropsychopharmacology 30 (7): 1257–68. DOI:10.1038/sj.npp.1300677. PMID 15688083.

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CP-226,269

Reference[uredi | uredi kod]

Spoljašnje veze[uredi | uredi kod]

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