5-HT2C receptor

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5-hidroksitriptaminski (serotoninski) receptor 2C
Identifikatori
Simboli HTR2C; 5-HT2C; 5-HTR2C; HTR1C
Vanjski ID OMIM312861 MGI96281 HomoloGene20242 GeneCards: HTR2C Gene
Pregled RNK izražavanja
PBB GE HTR2C 211479 s at tn.png
PBB GE HTR2C 207307 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 3358 15560
Ensembl ENSG00000147246 ENSMUSG00000041380
UniProt P28335 Q8BUB1
RefSeq (mRNA) NM_000868.2 NM_008312.4
RefSeq (protein) NP_000859.1 NP_032338.3
Lokacija (UCSC) Chr X:
113.82 - 114.14 Mb
Chr X:
143.4 - 143.63 Mb
PubMed pretraga [1] [2]

5-HT2C receptor je tip 5-HT receptor koji vezuje endogeni neurotransmiter serotonin (5-hidroksitriptamin, 5-HT). On je G protein-spregnuti receptor (GPCR) koji deluje kro Gq/G11 i posreduje ekscitatornu neurotransmisiju. HTR2C isto tako označava humani gen koji kodira receptor,[1][2] koji je lociran na X hromozomu. Pošto muškarci imaju jednu kopiju ovog gena, a kod žena jedna od kopija je represivna, polimorfizmi ovog receptora mogu da imaju različiti uticaj u zavisnosti od pola.

Distribucija[uredi - уреди]

5-HT2C receptori su distribuirani širom perifernog humanog mozga.

Funkcija[uredi - уреди]

5-HT2C receptor je jedno od mnogih mesta vezivanja serotonina. Aktivacija ovog receptora serotoninom inhibira otpuštanje dopamina i norepinefrina u pojedinim oblastima mozga.[3]

5-HT2C receptori imaju znatan udeo u regulaciji raspoloženja, anksioznosti, ishrani, i reproduktivnom ponašanju.[4] 5-HT2C receptori regulišu dopaminsko otpuštanje u striatumu, prefrontalnom korteksu, nucleus accumbensu, hipokampusu, hipotalamusu, i amigdali, između ostalih.

Ligandi[uredi - уреди]

Agonisti
Antagonisti
Inverzni Agonisti

Interakcije[uredi - уреди]

Za 5-HT2C receptor je pokazano da interaguje sa MPDZ.[5][6]

Vidi još[uredi - уреди]

Reference[uredi - уреди]

  1. "Entrez Gene: HTR2C 5-hydroxytryptamine (serotonin) receptor 2C". http://www.ncbi.nlm.nih.gov/gene/3358?ordinalpos=2&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum. 
  2. Stam NJ, Vanderheyden P, van Alebeek C, Klomp J, de Boer T, van Delft AM, Olijve W (November 1994). "Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor". Eur. J. Pharmacol. 269 (3): 339–48. doi:10.1016/0922-4106(94)90042-6. PMID 7895773. 
  3. Alex KD, Yavanian GJ, McFarlane HG, Pluto CP, Pehek EA (March 2005). "Modulation of dopamine release by striatal 5-HT2C receptors". Synapse 55 (4): 242–51. doi:10.1002/syn.20109. PMID 15668911. 
  4. Heisler LK, Zhou L, Bajwa P, Hsu J, Tecott LH (July 2007). "Serotonin 5-HT2C receptors regulate anxiety-like behavior". Genes, Brain and Behavior 6 (5): 491–6. doi:10.1111/j.1601-183X.2007.00316.x. PMID 17451451. 
  5. Becamel, C; Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C (Apr. 2001). "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1". J. Biol. Chem. (United States) 276 (16): 12974–82. doi:10.1074/jbc.M008089200. ISSN 0021-9258. PMID 11150294. 
  6. Ullmer, C; Schmuck K, Figge A, Lübbert H (Mar. 1998). "Cloning and characterization of MUPP1, a novel PDZ domain protein". FEBS Lett. (NETHERLANDS) 424 (1-2): 63–8. doi:10.1016/S0014-5793(98)00141-0. ISSN 0014-5793. PMID 9537516. 

Literatura[uredi - уреди]

  • Niswender CM, Sanders-Bush E, Emeson RB (1999). "Identification and characterization of RNA editing events within the 5-HT2C receptor.". Ann. N. Y. Acad. Sci. 861 (1 ADVANCES IN S): 38–48. doi:10.1111/j.1749-6632.1998.tb10171.x. PMID 9928237. 
  • Hoyer D, Hannon JP, Martin GR (2002). "Molecular, pharmacological and functional diversity of 5-HT receptors.". Pharmacol. Biochem. Behav. 71 (4): 533–54. doi:10.1016/S0091-3057(01)00746-8. PMID 11888546. 
  • Raymond JR, Mukhin YV, Gelasco A, et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction.". Pharmacol. Ther. 92 (2-3): 179–212. doi:10.1016/S0163-7258(01)00169-3. PMID 11916537. 
  • Van Oekelen D, Luyten WH, Leysen JE (2003). "5-HT2A and 5-HT2C receptors and their atypical regulation properties.". Life Sci. 72 (22): 2429–49. doi:10.1016/S0024-3205(03)00141-3. PMID 12650852. 
  • Reynolds GP, Templeman LA, Zhang ZJ (2005). "The role of 5-HT2C receptor polymorphisms in the pharmacogenetics of antipsychotic drug treatment.". Prog. Neuropsychopharmacol. Biol. Psychiatry 29 (6): 1021–8. doi:10.1016/j.pnpbp.2005.03.019. PMID 15953671. 
  • Millan MJ (2006). "Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies.". Therapie 60 (5): 441–60. doi:10.2515/therapie:2005065. PMID 16433010. 
  • Milatovich A, Hsieh CL, Bonaminio G, et al. (1993). "Serotonin receptor 1c gene assigned to X chromosome in human (band q24) and mouse (bands D-F4).". Hum. Mol. Genet. 1 (9): 681–4. doi:10.1093/hmg/1.9.681. PMID 1302605. 
  • Saltzman AG, Morse B, Whitman MM, et al. (1992). "Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes.". Biochem. Biophys. Res. Commun. 181 (3): 1469–78. doi:10.1016/0006-291X(91)92105-S. PMID 1722404. 
  • Lappalainen J, Zhang L, Dean M, et al. (1995). "Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C).". Genomics 27 (2): 274–9. doi:10.1006/geno.1995.1042. PMID 7557992. 
  • Tecott LH, Sun LM, Akana SF, et al. (1995). "Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors.". Nature 374 (6522): 542–6. doi:10.1038/374542a0. PMID 7700379. 
  • Stam NJ, Vanderheyden P, van Alebeek C, et al. (1995). "Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor.". Eur. J. Pharmacol. 269 (3): 339–48. doi:10.1016/0922-4106(94)90042-6. PMID 7895773. 
  • Xie E, Zhu L, Zhao L, Chang LS (1996). "The human serotonin 5-HT2C receptor: complete cDNA, genomic structure, and alternatively spliced variant.". Genomics 35 (3): 551–61. doi:10.1006/geno.1996.0397. PMID 8812491. 
  • Burns CM, Chu H, Rueter SM, et al. (1997). "Regulation of serotonin-2C receptor G-protein coupling by RNA editing.". Nature 387 (6630): 303–8. doi:10.1038/387303a0. PMID 9153397. 
  • Brennan TJ, Seeley WW, Kilgard M, et al. (1997). "Sound-induced seizures in serotonin 5-HT2c receptor mutant mice.". Nat. Genet. 16 (4): 387–90. doi:10.1038/ng0897-387. PMID 9241279. 
  • Ullmer C, Schmuck K, Figge A, Lübbert H (1998). "Cloning and characterization of MUPP1, a novel PDZ domain protein.". FEBS Lett. 424 (1-2): 63–8. doi:10.1016/S0014-5793(98)00141-0. PMID 9537516. 
  • Samochowiec J, Smolka M, Winterer G, et al. (1999). "Association analysis between a Cys23Ser substitution polymorphism of the human 5-HT2c receptor gene and neuronal hyperexcitability.". Am. J. Med. Genet. 88 (2): 126–30. doi:10.1002/(SICI)1096-8628(19990416)88:2<126::AID-AJMG6>3.0.CO;2-M. PMID 10206230. 
  • Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes.". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209. 
  • Marshall SE, Bird TG, Hart K, Welsh KI (2000). "Unified approach to the analysis of genetic variation in serotonergic pathways.". Am. J. Med. Genet. 88 (6): 621–7. doi:10.1002/(SICI)1096-8628(19991215)88:6<621::AID-AJMG9>3.0.CO;2-H. PMID 10581480. 
  • Backstrom JR, Price RD, Reasoner DT, Sanders-Bush E (2000). "Deletion of the serotonin 5-HT2C receptor PDZ recognition motif prevents receptor phosphorylation and delays resensitization of receptor responses.". J. Biol. Chem. 275 (31): 23620–6. doi:10.1074/jbc.M000922200. PMID 10816555.