TRHR
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| Tirotropin-oslobađajući hormonski receptor | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | TRHR; MGC141920 | ||||||||||
| Vanjski ID | OMIM: 188545 MGI: 98824 HomoloGene: 20707 IUPHAR: TRH1 GeneCards: TRHR Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 7201 | 22045 | |||||||||
| Ensembl | ENSG00000174417 | ENSMUSG00000038760 | |||||||||
| UniProt | P34981 | Q32MS1 | |||||||||
| RefSeq (mRNA) | NM_003301 | NM_013696 | |||||||||
| RefSeq (protein) | NP_003292 | NP_038724 | |||||||||
| Lokacija (UCSC) | Chr 8: 110.17 - 110.2 Mb | Chr 15: 44.03 - 44.06 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
TRHR (tirotropin-oslobađajući hormonski receptor) je G protein-spregnuti receptor koji vezuje tripeptid tireotropin oslobađajući hormon.[1][2] TRHR je nađen u mozgu. Kad je ovaj receptor vezan za TRH dejstvuje kroz fosfolipazu C i povišava intracelularnu koncentraciju inozitol trifosfata.
Reference[uredi | uredi kod]
- ↑ Yamada M, Monden T, Konaka S, Mori M (1993). „Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8”. Somat. Cell Mol. Genet. 19 (6): 577–80. DOI:10.1007/BF01233384. PMID 8128317.
- ↑ Gershengorn MC (1993). „Thyrotropin-releasing hormone receptor: cloning and regulation of its expression”. Recent Prog. Horm. Res. 48: 341–63. PMID 8382829.
Literatura[uredi | uredi kod]
- Short RE, James LF, Panter KE, et al. (1993). „Effects of feeding ponderosa pine needles during pregnancy: comparative studies with bison, cattle, goats, and sheep.”. J. Anim. Sci. 70 (11): 3498–504. PMID 1459912.
- Yamada M, Iwasaki T, Satoh T, et al. (1996). „Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly.”. Neurosci. Lett. 196 (1-2): 109–12. DOI:10.1016/0304-3940(95)11861-P. PMID 7501234.
- Hinuma S, Hosoya M, Ogi K, et al. (1994). „Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene.”. Biochim. Biophys. Acta 1219 (2): 251–9. PMID 7918619.
- Morrison N, Duthie SM, Boyd E, et al. (1994). „Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization.”. Hum. Genet. 93 (6): 716–8. PMID 8005602.
- Yamada M, Monden T, Konaka S, Mori M (1994). „Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8.”. Somat. Cell Mol. Genet. 19 (6): 577–80. DOI:10.1007/BF01233384. PMID 8128317.
- Duthie SM, Taylor PL, Anderson L, et al. (1994). „Cloning and functional characterisation of the human TRH receptor.”. Mol. Cell. Endocrinol. 95 (1-2): R11–5. DOI:10.1016/0303-7207(93)90043-J. PMID 8243797.
- Matre V, Karlsen HE, Wright MS, et al. (1993). „Molecular cloning of a functional human thyrotropin-releasing hormone receptor.”. Biochem. Biophys. Res. Commun. 195 (1): 179–85. DOI:10.1006/bbrc.1993.2027. PMID 8395824.
- Yamada M, Monden T, Satoh T, et al. (1993). „Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene.”. Biochem. Biophys. Res. Commun. 195 (2): 737–45. DOI:10.1006/bbrc.1993.2107. PMID 8396925.
- Iwasaki T, Yamada M, Satoh T, et al. (1996). „Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene.”. J. Biol. Chem. 271 (36): 22183–8. DOI:10.1074/jbc.271.36.22183. PMID 8703031.
- Cook JV, McGregor A, Lee T, et al. (1996). „A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor.”. Endocrinology 137 (7): 2851–8. DOI:10.1210/en.137.7.2851. PMID 8770906.
- Collu R, Tang J, Castagné J, et al. (1997). „A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene.”. J. Clin. Endocrinol. Metab. 82 (5): 1561–5. DOI:10.1210/jc.82.5.1561. PMID 9141550.
- Petrou C, Tashjian AH (1999). „The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles.”. Cell. Signal. 10 (8): 553–9. DOI:10.1016/S0898-6568(97)00190-3. PMID 9794253.
- Matre V, Høvring PI, Orstavik S, et al. (1999). „Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor.”. J. Neurochem. 72 (1): 40–50. DOI:10.1046/j.1471-4159.1999.0720040.x. PMID 9886052.
- Kroeger KM, Hanyaloglu AC, Seeber RM, et al. (2001). „Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer.”. J. Biol. Chem. 276 (16): 12736–43. DOI:10.1074/jbc.M011311200. PMID 11278883.
- Zhu CC, Cook LB, Hinkle PM (2002). „Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation.”. J. Biol. Chem. 277 (31): 28228–37. DOI:10.1074/jbc.M204221200. PMID 12023974.
- Hanyaloglu AC, Seeber RM, Kohout TA, et al. (2003). „Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.”. J. Biol. Chem. 277 (52): 50422–30. DOI:10.1074/jbc.M209340200. PMID 12393857.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Cook LB, Zhu CC, Hinkle PM (2004). „Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation.”. Mol. Endocrinol. 17 (9): 1777–91. DOI:10.1210/me.2003-0073. PMID 12805411.
- Igarashi-Migitaka J, Yamada S, Hara M, et al. (2004). „Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas.”. Endocr. J. 50 (4): 459–67. DOI:10.1507/endocrj.50.459. PMID 14599121.
- Cook LB, Hinkle PM (2004). „Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein.”. Endocrinology 145 (7): 3095–100. DOI:10.1210/en.2004-0304. PMID 15117874.
Spoljašnje veze[uredi | uredi kod]
- „Thyrotropin-Releasing Hormone Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2012-09-08.
- MeSH Receptors,+Thyrotropin-Releasing+Hormone