Fisalaemin

Izvor: Wikipedia
Fisalaemin
Physalaemin.svg
Identifikacija
CAS registarski broj 2507-24-6 YesY
PubChem[1][2] 17268
MeSH Physalaemin
ChEMBL[3] CHEMBL415235 YesY
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C58H84N14O16S
Molarna masa 1265.44 g/mol

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Fisalaemin je tahikininski peptid dobijen iz Physalaemus žaba. On je blisko srodan sa supstancom P. Njegova struktura je prvi put utvrđena 1964.[4][5]

Poput svih tahikinina, fisalaemin povećava salivaciju, i deluje kao potentan vazodilatator sa hipotenzivnim efektima.[6]

Literatura[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  4. Erspaemer V, Anastasi A, Bertaccini G, Cei JM (1964). "Structure and pharmacological actions of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Experientia 20 (9): 489–90. doi:10.1007/BF02154064. PMID 5857249. 
  5. Anastasi A, Erspamer V, Cei JM (1964). "Isolation and amino acid sequence of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Arch Biochem Biophys 108 (2): 341–8. doi:10.1016/0003-9861(64)90395-9. PMID 14240587. 
  6. Severini C, Improta G, Falconieri-Erspamer G, Salvadori S, Erspamer V (2002). "The tachykinin peptide family". Pharmacol Rev 54 (2): 285–322. doi:10.1124/pr.54.2.285. PMID 12037144.  Free full text

Spoljašnje veze[uredi - уреди]