Moždano specifični angiogenezni inhibitor 1

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Moždano specifični angiogenezni inhibitor 1
Identifikatori
Simboli BAI1; GDAIF
Vanjski ID OMIM602682 MGI1933736 HomoloGene1287 IUPHAR: BAI1 GeneCards: BAI1 Gene
Pregled RNK izražavanja
PBB GE BAI1 206083 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 575 107831
Ensembl ENSG00000181790 ENSMUSG00000034730
UniProt O14514 Q3UHD1
RefSeq (mRNA) NM_001702.2 NM_174991.3
RefSeq (protein) NP_001693.2 NP_778156.2
Lokacija (UCSC) Chr 8:
143.53 - 143.63 Mb
Chr 15:
74.35 - 74.42 Mb
PubMed pretraga [1] [2]

Moždano specifični angiogenezni inhibitor 1 je protein koji je kod ljudi kodiran BAI1 genom.[1][2] On je inhibitor angiogeneze i supresor rasta glioblastoma.[2]

Angiogeneza je kontrolisana lokalnim balansom između stimulatora i inhibitora rasta novih krvnih sudova, i supresovana je pod normalnim fiziološkim uslovima. Angiogeneza je esencijalna za rast i metastazu čvrstih tumora. Da bi obezbedile snabdevanje krvi koji je neophodno za njihov rast, ćelije tumora su potentno angiogene i privlače nove krvne sudove usled povišene sekrecije induktivnih agenasa i umanjene produkcije endogenih negativnih regulatora. BAI1 sadrži najmanje jedano funkcionalno p53 mesto vezivanja unutar introna, i njegovo izražavanje može da bude indukovano p53 faktorom. Postoje dva druga gena moždano specifičnih angiogeneznih inhibitor, BAI2 i BAI3, koji zajedno sa BAI1 imaju slične tkivne karakteristike i strukture, međutim samo BAI1 je transkripciono regulisan p53 proteinom. BAI1 je član sekretinske receptorske familije.

Interakcije[uredi - уреди]

Moždano specifični angiogenezni inhibitor 1 formira interakcije sa BAIAP3[3] i MAGI1.[4]

Reference[uredi - уреди]

  1. Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenet Cell Genet 79 (1–2): 103–8. doi:10.1159/000134693. PMID 9533023. 
  2. 2.0 2.1 "Entrez Gene: BAI1 brain-specific angiogenesis inhibitor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=575. 
  3. Shiratsuchi, T; Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T, Nakamura Y (Oct. 1998). "Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1". Biochem. Biophys. Res. Commun. (UNITED STATES) 251 (1): 158–65. doi:10.1006/bbrc.1998.9408. ISSN 0006-291X. PMID 9790924.  Check date values in: |date= (help)
  4. Shiratsuchi, T; Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T (Jun. 1998). "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochem. Biophys. Res. Commun. (UNITED STATES) 247 (3): 597–604. doi:10.1006/bbrc.1998.8603. ISSN 0006-291X. PMID 9647739.  Check date values in: |date= (help)

Literatura[uredi - уреди]

  • Van Meir EG, Polverini PJ, Chazin VR et al. (1995). "Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells". Nat. Genet. 8 (2): 171–6. doi:10.1038/ng1094-171. PMID 7531056. 
  • Nishimori H, Shiratsuchi T, Urano T et al. (1997). "A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis". Oncogene 15 (18): 2145–50. doi:10.1038/sj.onc.1201542. PMID 9393972. 
  • Shiratsuchi T, Futamura M, Oda K et al. (1998). "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochem. Biophys. Res. Commun. 247 (3): 597–604. doi:10.1006/bbrc.1998.8603. PMID 9647739. 
  • Fukushima Y, Oshika Y, Tsuchida T et al. (1998). "Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer". Int. J. Oncol. 13 (5): 967–70. PMID 9772287. 
  • Shiratsuchi T, Oda K, Nishimori H et al. (1998). "Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1". Biochem. Biophys. Res. Commun. 251 (1): 158–65. doi:10.1006/bbrc.1998.9408. PMID 9790924. 
  • Oda K, Shiratsuchi T, Nishimori H et al. (1999). "Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1". Cytogenet. Cell Genet. 84 (1–2): 75–82. doi:10.1159/000015219. PMID 10343108. 
  • Wu Y, Dowbenko D, Spencer S et al. (2000). "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase". J. Biol. Chem. 275 (28): 21477–85. doi:10.1074/jbc.M909741199. PMID 10748157. 
  • Koh JT, Lee ZH, Ahn KY et al. (2001). "Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein". Brain Res. Mol. Brain Res. 87 (2): 223–37. doi:10.1016/S0169-328X(01)00004-3. PMID 11245925. 
  • Duda DG, Sunamura M, Lozonschi L et al. (2002). "Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis". Br. J. Cancer 86 (3): 490–6. doi:10.1038/sj.bjc.6600067. PMC 2375213. PMID 11875720. 
  • Lim IA, Hall DD, Hell JW (2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. 277 (24): 21697–711. doi:10.1074/jbc.M112339200. PMID 11937501. 
  • Mori K, Kanemura Y, Fujikawa H et al. (2002). "Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells". Neurosci. Res. 43 (1): 69–74. doi:10.1016/S0168-0102(02)00018-4. PMID 12074842. 
  • Kaur B, Brat DJ, Calkins CC, Van Meir EG (2003). "Brain Angiogenesis Inhibitor 1 Is Differentially Expressed in Normal Brain and Glioblastoma Independently of p53 Expression". Am. J. Pathol. 162 (1): 19–27. doi:10.1016/S0002-9440(10)63794-7. PMC 1851137. PMID 12507886. 
  • Adkins JN, Varnum SM, Auberry KJ et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Mol. Cell Proteomics 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Koh JT, Kook H, Kee HJ et al. (2004). "Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin". Exp. Cell Res. 294 (1): 172–84. doi:10.1016/j.yexcr.2003.11.008. PMID 14980512. 
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.