LPHN3

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Latrofilin 3
Identifikatori
Simboli LPHN3; CIRL3; LEC3
Vanjski ID MGI2441950 HomoloGene22878 IUPHAR: LPHN3 GeneCards: LPHN3 Gene
Ortolozi
Vrsta Čovek Miš
Entrez 23284 319387
Ensembl ENSG00000150471 ENSMUSG00000037605
UniProt Q9HAR2 Q80TS3
RefSeq (mRNA) NM_015236.4 NM_198702.2
RefSeq (protein) NP_056051.2 NP_941991.1
Lokacija (UCSC) Chr 4:
62.07 - 62.94 Mb
Chr 5:
81.45 - 82.25 Mb
PubMed pretraga [1] [2]

Latrofilin-3 je protein koji je kod ljudi kodiran LPHN3 genom.[1][2]

Function[uredi - уреди]

Ovaj protein je član latrofilinske familije G protein spregnutih receptora (GPCR). Latrofilini mogu da učestvuju u ćelijskoj adheziji i u prenosu signala. Endogeno proteolitičko razlaganje unutar cisteinom bogatog GPS (GPCR proteolizno mesto) domena proizvodi dve podjedinice (veliku ekstracelularnu N-terminalnu adhezionu jedinicu i podjedinicu koja je u znatno meri slična sa sekretinskom/kalcitoninskom familijom). [2]

Klinički značaj[uredi - уреди]

Jedna verzija ovog gena je povezana sa hiperkinetičkim poremećajem (ADHD).[3]

Reference[uredi - уреди]

  1. Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families". J Recept Signal Transduct Res 20 (2–3): 119–31. DOI:10.3109/10799890009150640. PMID 10994649. 
  2. 2.0 2.1 "Entrez Gene: LPHN3 latrophilin 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23284. 
  3. Arcos-Burgos M, Jain M, Acosta MT, et al. (November 2010). "A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication". Mol. Psychiatry 15 (11): 1053–66. DOI:10.1038/mp.2010.6. PMID 20157310. 

Literatura[uredi - уреди]

  • Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins". Annu. Rev. Neurosci. 24: 933–62. DOI:10.1146/annurev.neuro.24.1.933. PMID 11520923. 
  • Ushkaryov YA, Volynski KE, Ashton AC (2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies". Toxicon 43 (5): 527–42. DOI:10.1016/j.toxicon.2004.02.008. PMID 15066411. 
  • Soares MB, Bonaldo MF, Jelene P, et al. (1994). "Construction and characterization of a normalized cDNA library". Proc. Natl. Acad. Sci. U.S.A. 91 (20): 9228–32. DOI:10.1073/pnas.91.20.9228. PMID 7937745. 
  • (1999) "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. DOI:10.1101/gr.8.11.1097. PMID 9847074. 
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. DOI:10.1093/dnares/5.5.277. PMID 9872452. 
  • Kreienkamp HJ, Zitzer H, Gundelfinger ED, et al. (2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". J. Biol. Chem. 275 (42): 32387–90. DOI:10.1074/jbc.C000490200. PMID 10964907. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics 84 (1): 23–33. DOI:10.1016/j.ygeno.2003.12.004. PMID 15203201. 

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