Histaminski H1 receptor

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Histamine receptor H1

Histaminski H1 receptor u kompleksu sa doksepinom (3RZE)
Dostupne strukture
3RZE
Identifikatori
Simboli HRH1; H1-R; hisH1
Vanjski ID OMIM600167 MGI107619 HomoloGene668 IUPHAR: H1 GeneCards: HRH1 Gene
Pregled RNK izražavanja
PBB GE HRH1 205579 at tn.png
PBB GE HRH1 205580 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 3269 15465
Ensembl ENSG00000196639 ENSMUSG00000053004
UniProt P35367 P70174
RefSeq (mRNA) NM_000861.3 NM_001252642.1
RefSeq (protein) NP_000852.1 NP_001239571.1
Lokacija (UCSC) Chr 3:
11.18 - 11.31 Mb
Chr 6:
114.35 - 114.43 Mb
PubMed pretraga [1] [2]

H1 receptor je histaminski receptor iz familije rodopsinu sličnih G protein spregnutih receptora. Ovaj receptor, koji aktivira biogeni amin histamin, je izražen širom tela, u glatkim mišićima, vaskularnim endotelnim ćelijama, u srcu, i u centralnom nervnom sistemu. H1 receptor je spregnut sa intracelularnim G proteinom (Gq) koji aktivira signalni put fosfolipaze C i fosfatidilinozitola (PIP2). Antihistamini koji deluju na ovaj receptor se koriste kao lekovi protiv alergije. Kristalna struktura receptora je određena.[1]

Reference[uredi - уреди]

  1. Tatsuro Shimamura, Mitsunori Shiroishi, Simone Weyand, Hirokazu Tsujimoto, Graeme Winter, Vsevolod Katritch, Ruben Abagyan, Vadim Cherezov, Wei Liu, Gye Won Han, Takuya Kobayashi, Raymond C. Stevens & So Iwata (July 2011). "Structure of the human histamine H1 receptor complex with doxepin". Nature 475 (7354): 65–70. doi:10.1038/nature10236. PMID 21697825. 

Literatura[uredi - уреди]

  • Mitsuchashi M, Payan DG (1989). "Molecular and cellular analysis of histamine H1 receptors on cultured smooth muscle cells.". J. Cell. Biochem. 40 (2): 183–92. doi:10.1002/jcb.240400207. PMID 2670975. 
  • Braman SS (1987). "Histamine receptors in the lung.". N Engl Reg Allergy Proc 8 (2): 116–20. doi:10.2500/108854187778994446. PMID 2886904. 
  • Hill SJ, Ganellin CR, Timmerman H, et al. (1997). "International Union of Pharmacology. XIII. Classification of histamine receptors.". Pharmacol. Rev. 49 (3): 253–78. PMID 9311023. 
  • Holden CA, Chan SC, Norris S, Hanifin JM (1988). "Histamine induced elevation of cyclic AMP phosphodiesterase activity in human monocytes.". Agents Actions 22 (1–2): 36–42. doi:10.1007/BF01968814. PMID 2891264. 
  • Moguilevsky N, Varsalona F, Noyer M, et al. (1994). "Stable expression of human H1-histamine-receptor cDNA in Chinese hamster ovary cells. Pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene". Eur. J. Biochem. 224 (2): 489–95. doi:10.1111/j.1432-1033.1994.00489.x. PMID 7925364. 
  • Fukui H, Fujimoto K, Mizuguchi H, et al. (1994). "Molecular cloning of the human histamine H1 receptor gene". Biochem. Biophys. Res. Commun. 201 (2): 894–901. doi:10.1006/bbrc.1994.1786. PMID 8003029. 
  • Le Coniat M, Traiffort E, Ruat M, et al. (1994). "Chromosomal localization of the human histamine H1-receptor gene". Hum. Genet. 94 (2): 186–8. PMID 8045566. 
  • De Backer MD, Gommeren W, Moereels H, et al. (1994). "Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor". Biochem. Biophys. Res. Commun. 197 (3): 1601–8. doi:10.1006/bbrc.1993.2662. PMID 8280179. 
  • Hishinuma S, Young JM (1996). "Characteristics of the binding of [3H]-mepyramine to intact human U373 MG astrocytoma cells: evidence for histamine-induced H1-receptor internalisation". Br. J. Pharmacol. 116 (6): 2715–23. PMC 1909113. PMID 8590995. 
  • Max SI, Chowdhury BA, Fraser CM (1996). "Sequence analysis of the 5'-untranslated region of the human H1 histamine receptor-encoding gene". Gene 171 (2): 309–10. doi:10.1016/0378-1119(96)00036-4. PMID 8666296. 
  • De Backer MD, Loonen I, Verhasselt P, et al. (1998). "Structure of the human histamine H1 receptor gene". Biochem. J. 335 (3): 663–70. PMC 1219830. PMID 9794809. 
  • Horváth BV, Szalai C, Mándi Y, et al. (1999). "Histamine and histamine-receptor antagonists modify gene expression and biosynthesis of interferon gamma in peripheral human blood mononuclear cells and in CD19-depleted cell subsets". Immunol. Lett. 70 (2): 95–9. doi:10.1016/S0165-2478(99)00126-1. PMID 10569698. 
  • Wang KY, Arima N, Higuchi S, et al. (2000). "Switch of histamine receptor expression from H2 to H1 during differentiation of monocytes into macrophages". FEBS Lett. 473 (3): 345–8. doi:10.1016/S0014-5793(00)01560-X. PMID 10818238. 
  • Oda T, Morikawa N, Saito Y, et al. (2001). "Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes". J. Biol. Chem. 275 (47): 36781–6. doi:10.1074/jbc.M006480200. PMID 10973974. 
  • Brew OB, Sullivan MH (2002). "Localisation of mRNAs for diamine oxidase and histamine receptors H1 and H2, at the feto-maternal interface of human pregnancy". Inflamm. Res. 50 (9): 449–52. doi:10.1007/PL00000269. PMID 11603849. 
  • Gutzmer R, Langer K, Lisewski M, et al. (2002). "Expression and function of histamine receptors 1 and 2 on human monocyte-derived dendritic cells". J. Allergy Clin. Immunol. 109 (3): 524–31. doi:10.1067/mai.2002.121944. PMID 11898002. 
  • Idzko M, la Sala A, Ferrari D, et al. (2002). "Expression and function of histamine receptors in human monocyte-derived dendritic cells". J. Allergy Clin. Immunol. 109 (5): 839–46. doi:10.1067/mai.2002.124044. PMID 11994709. 

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