5-HT1D receptor

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5-hidroksitriptaminski (serotoninski) receptor 1D
Identifikatori
Simboli HTR1D; 5-HT1D; HT1DA; HTR1DA; HTRL; RDC4
Vanjski ID OMIM182133 MGI96276 HomoloGene20240 IUPHAR: 5-HT1D GeneCards: HTR1D Gene
Pregled RNK izražavanja
PBB GE HTR1D 207368 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 3352 15552
Ensembl ENSG00000179546 ENSMUSG00000070687
UniProt P28221 Q3ZB48
RefSeq (mRNA) NM_000864 NM_008309
RefSeq (protein) NP_000855 NP_032335
Lokacija (UCSC) Chr 1:
23.39 - 23.39 Mb
Chr 4:
135.7 - 135.72 Mb
PubMed pretraga [1] [2]

5-HT1D receptor (5-hidroksitriptaminski (serotoninski) receptor 1D, HTR1D) je 5-HT receptor. On je kodiran istoimenim genom.[1] 5-HT1D deluje na centralni nervni sistem, i utiče na kretanje i anksioznost. On takoše indukuje vaskularnu vazokonstrikciju u mozgu.

Ligandi[uredi - уреди]

Agonisti[uredi - уреди]

  • 5-(Noniloksi)triptamin,[2]
  • sumatriptan (vazokonstriktor kod migraine)
  • 5-Karboksamidotriptamin (5-CT)
  • 5-(t-Butil)-N-metiltriptamin[3]
  • CP-286,601
  • PNU-109,291 ((S)-3,4-Dihidro-1-[2-[4-(4-metoksifenil)-1-piperazinil]etil]-N-metil-1H-2-benzopiran-6-karboksamid)
  • PNU-142,633 ((1S)-1-[2-[4-[4-(Aminokarbonil)fenil]-1-piperazinil]etil]-3,4-dihidro-N-metil-1H-2-benzopiran-6-karboksamid)
  • GR-46611 (3-[3-(2-Dimetilaminoetil)-1H-indol-5-il]-N-(4-metoksibenzil)akrilamid)
  • L-694,247 (2-[5-[3-(4-Metilsulfonilamino)benzil-1,2,4-oksadiazol-5-il]-1H-indol-3-il]etanamin)
  • L-772,405

Antagonisti

Vidi još[uredi - уреди]

Literatura[uredi - уреди]

  1. "Entrez Gene: HTR1D 5-hydroxytryptamine (serotonin) receptor 1D". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3352. 
  2. Glennon RA, Hong SS, Dukat M, Teitler M, Davis K (1994). "5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist". J. Med. Chem. 37 (18): 2828–30. doi:10.1021/jm00044a001. PMID 8071931. 
  3. Xu, YC; Schaus, JM; Walker, C; Krushinski, J; Adham, N; Zgombick, JM; Liang, SX; Kohlman, DT et al. (1999). "N-Methyl-5-tert-butyltryptamine: A novel, highly potent 5-HT1D receptor agonist.". Journal of medicinal chemistry 42 (3): 526–31. doi:10.1021/jm9805945. PMID 9986723. 
  4. "Essential psychopharmacology: neuroscientific basis and practical applications". http://books.google.com/books?id=HkA0Q31YDhAC&pg=PA438&lpg=PA438&dq=antipsychotics+5ht1d&source=web&ots=dSBm26DKPf&sig=3GtDECBspZW7_O1y6zJHd04BFo8#PPA438,M1. 

Dodatna literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]