GNRHR2
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| Gonadotropin-oslobađajući hormonski receptor II | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | GNRHR2; GnRH-II-R | ||||||||||
| Vanjski ID | IUPHAR: GnRH2 GeneCards: GNRHR2 Gene | ||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 114814 | n/a | |||||||||
| Ensembl | ENSG00000211451 | n/a | |||||||||
| UniProt | Q96P88 | n/a | |||||||||
| RefSeq (mRNA) | NR_002328 | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Lokacija (UCSC) | Chr 1: 145.51 - 145.52 Mb | n/a | |||||||||
| PubMed pretraga | [1] | n/a | |||||||||
GNRHR2, gonadotropin-oslobađajući hormonski receptor II, je protein koji je kod ljudi kodiran GNRHR2 genom.[1][2]
Receptor gonadotropin oslobađajućeg hormona 2 (GnRH2) je G protein spregnuti receptor, koji je kodiran GnRHR2 genom kod ne-hominoidnih primata i ne-sisarskih kičmenjaka. Kod ljudi, N-terminus protein ima pomeranje okvira čitanja sekvence i prerani stop kodon. Mada dolazi do transkripcije, još uvek nije potpuno razjašnjeno da li je receptor funkcionalan. Alternativne splajsne varijante su poznate. Nentranskribovani GnRHR2 pseudogen takođe postoji na hromozomu 14.[2]
Vidi još[uredi | uredi kod]
Reference[uredi | uredi kod]
- ↑ Faurholm B, Millar RP, Katz AA (Nov 2001). „The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci”. Genomics 78 (1–2): 15–8. DOI:10.1006/geno.2001.6650. PMID 11707068.
- ↑ 2,0 2,1 „Entrez Gene: GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2”.
Literatura[uredi | uredi kod]
- Neill JD (2002). „GnRH and GnRH receptor genes in the human genome”. Endocrinology 143 (3): 737–43. DOI:10.1210/en.143.3.737. PMID 11861490.
- Millar R, Conklin D, Lofton-Day C, et al. (1999). „A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript”. J. Endocrinol. 162 (1): 117–26. DOI:10.1677/joe.0.1620117. PMID 10396028.
- Neill JD, Duck LW, Sellers JC, Musgrove LC (2001). „A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates”. Biochem. Biophys. Res. Commun. 282 (4): 1012–8. DOI:10.1006/bbrc.2001.4678. PMID 11352653.
- van Biljon W, Wykes S, Scherer S, et al. (2003). „Type II gonadotropin-releasing hormone receptor transcripts in human sperm”. Biol. Reprod. 67 (6): 1741–9. DOI:10.1095/biolreprod.101.002808. PMID 12444048.
- Morgan K, Conklin D, Pawson AJ, et al. (2003). „A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12”. Endocrinology 144 (2): 423–36. DOI:10.1210/en.2002-220622. PMID 12538601.
- Pawson AJ, Maudsley S, Morgan K, et al. (2005). „Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment”. Endocrinology 146 (6): 2639–49. DOI:10.1210/en.2005-0133. PMID 15761034.
- Eicke N, Günthert AR, Viereck V, et al. (2005). „GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs”. Eur. J. Endocrinol. 153 (4): 605–12. DOI:10.1530/eje.1.02005. PMID 16189182.
- Ikemoto T, Park MK (2006). „Comparative genomics of the endocrine systems in humans and chimpanzees with special reference to GNRH2 and UCN2 and their receptors”. Genomics 87 (4): 459–62. DOI:10.1016/j.ygeno.2005.11.005. PMID 16406723.
- Parker JD, Malik M, Catherino WH (2007). „Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor”. Fertil. Steril. 88 (1): 39–46. DOI:10.1016/j.fertnstert.2006.11.098. PMID 17296196.
Spoljašnje veze[uredi | uredi kod]
- „Gonadotrophin-Releasing Hormone Receptors: GnRH2 Receptor”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.