Alfa-2 adrenergički receptor

Izvor: Wikipedia

Alfa-2 (α2) adrenergički receptor (ili adrenoceptor) je G protein-spregnuti receptor koji vezuje Gi heterotrimerni G protein. Postoje tri visoko homologna podtipa, α2A-, α2B-, i α2C- adrenergički receptor. Neke vrste takođe izražavaju četvrti α2D-adrenergički receptor.[1] Kateholamini kao što su norepinefrin (noradrenalin) i epinefrin (adrenalin) prenose signal kroz α2-adrenergički receptor u centralnom i perifernom nervnom sistemu.

Efekti[uredi - уреди]

α2-adrenergički receptor vezuje oba norepinefrin koga oslobađaju simpatička postgangliona vlakna i epinefrin (adrenalin) koga otpušta adrenalna medula. On vezuje epinefrin sa nešto većim afinitetom. On ima nekoliko opštih funkcija koje su zajedničke sa α1-adrenergičkim receptorom, a takođe ima i niz specifičnih efekata.

Opšti[uredi - уреди]

Opšti efekti su:

Individualni[uredi - уреди]

Individualna dejstva α2 receptora su:

Ligandi[uredi - уреди]

Vidi još[uredi - уреди]

Reference[uredi - уреди]

  1. Ruuskanen JO, Xhaard H, Marjamäki A, Salaneck E, Salminen T, Yan YL, Postlethwait JH, Johnson MS, Larhammar D, Scheinin M (January 2004). "Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish". Molecular Biology and Evolution 21 (1): 14–28. doi:10.1093/molbev/msg224. PMID 12949138. 
  2. Goodman Gilman, Alfred. Goodman & Gilman's The Pharmacological Basis of Therapeutics. Tenth Edition. McGraw-Hill (2001): Page 140.
  3. Woodman OL, Vatner SF (1987). "Coronary vasoconstriction mediated by α1- and α2-adrenoceptors in conscious dogs". Am. J. Physiol. 253 (2 Pt 2): H388–93. PMID 2887122. 
  4. Sun D, Huang A, Mital S, Kichuk MR, Marboe CC, Addonizio LJ, Michler RE, Koller A, Hintze TH, Kaley G (July 2002). "Norepinephrine elicits beta2-receptor-mediated dilation of isolated human coronary arterioles". Circulation 106 (5): 550–5. PMID 12147535. 
  5. Elliott J (1997). "Alpha-adrenoceptors in equine digital veins: evidence for the presence of both α1 and α2-receptors mediating vasoconstriction". J. Vet. Pharmacol. Ther. 20 (4): 308–17. doi:10.1046/j.1365-2885.1997.00078.x. PMID 9280371. 
  6. Sagrada A, Fargeas MJ, Bueno L (1987). "Involvement of α1 and α2 adrenoceptors in the postlaparotomy intestinal motor disturbances in the rat". Gut 28 (8): 955–9. doi:10.1136/gut.28.8.955. PMC 1433140. PMID 2889649. 
  7. 7.0 7.1 Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. str. 163. ISBN 0-443-07145-4. 
  8. Wright EE, Simpson ER (1981). "Inhibition of the lipolytic action of beta-adrenergic agonists in human adipocytes by alpha-adrenergic agonists". J. Lipid Res. 22 (8): 1265–70. PMID 6119348. 
  9. Fitzpatrick, David; Purves, Dale; Augustine, George (2004). "Table 20:2". Neuroscience (Third izd.). Sunderland, Mass: Sinauer. ISBN 0-87893-725-0. 
  10. Khan ZP, Ferguson CN, Jones RM (1999). "alpha-2 and imidazoline receptor agonists. Their pharmacology and therapeutic role". Anaesthesia 54 (2): 146–65. doi:10.1046/j.1365-2044.1999.00659.x. PMID 10215710. 
  11. 11.0 11.1 Haenisch B, Walstab J, Herberhold S, Bootz F, Tschaikin M, Ramseger R, Bönisch H. (2010 Dec). "Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline". Fundam Clin Pharmacol. 24 (6): 729–39. doi:10.1111/j.1472-8206.2009.00805.x. Check |doi= value (help). PMID 20030735. 

Literatura[uredi - уреди]

  • Fitzpatrick, David; Purves, Dale; Augustine, George (2004). "Table 20:2". Neuroscience (Third izd.). Sunderland, Mass: Sinauer. ISBN 0-87893-725-0. 
  • Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. str. 163. ISBN 0-443-07145-4. 

Spoljašnje veze[uredi - уреди]