Feniletanolamin N-metiltransferaza
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| Feniletanolamin N-metiltransferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.1.1.28 | ||||||||
| CAS broj | 9037-68-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Feniletanolamin N-metiltransferaza (EC 2.1.1.28, noradrenalinska N-metiltransferaza, noradrenalinska N-metiltransferaza, norepinefrin metiltransferaza, norepinefrinska N-metiltransferaza, fenetanolaminska metiltransferaza, fenetanolaminska N-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:feniletanolamin N-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + feniletanolamin S-adenozil-L-homocistein + N-metilfeniletanolamin
Ovaj enzim deluje na razne feniletanolamine. On konvertuje noradrenalin u adrenalin.
Reference[uredi | uredi kod]
- ↑ Axelrod, J. (1962). „Purification and properties of phenylethanolamine-N-methyl transferase”. J. Biol. Chem. 237: 1657-1660. PMID 13863458.
- ↑ Connett, R.J. and Kirschner, N. (1970). „Purification and properties of bovine phenylethanolamine N-methyltransferase”. J. Biol. Chem. 245: 329-334. PMID 5412063.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.