SR 59230A
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| SR 59230A | |||
|---|---|---|---|
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| IUPAC ime |
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| Identifikacija | |||
| CAS registarski broj | 174689-39-5 | ||
| PubChem[1][2] | 5311452 | ||
| IUPHAR ligand | 547 | ||
| Jmol-3D slike | Slika 1 | ||
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| Svojstva | |||
| Molekulska formula | C21H27NO2 | ||
| Molarna masa | 325.44 g mol−1 | ||
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Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
| Infobox references | |||
SR 59230A je selektivni antagonist beta-3 adrenergičkog receptora.[3][4][5] On isto tako deluje na α1 adrenoceptorima pri visokim dozama.[6] On blokira hipertermiju proizvedenu putem MDMA u životinjskim studijama.[7]
Reference[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Nisoli E, Tonello C, Landi M, Carruba MO (1996). „Functional studies of the first selective β3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes”. Mol. Pharmacol. 49 (1): 7–14. PMID 8569714.
- ↑ Bellantuono V, Cassano G, Lippe C (August 2008). „The adrenergic receptor subtypes present in frog (Rana esculenta) skin”. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 148 (2): 160–4. DOI:10.1016/j.cbpc.2008.05.001. PMID 18544474.
- ↑ Rickenbacher A, Seiler R, Honegger U, Shaw SG, Balsiger BM (January 2008). „Role of beta1-, beta2-, and beta3-adrenoceptors in contractile hypersensitivity in a model of small bowel transplantation”. Surgery 143 (1): 94–102. DOI:10.1016/j.surg.2007.06.034. PMID 18154937.
- ↑ Leblais V, Pourageaud F, Ivorra MD, Guibert C, Marthan R, Muller B (April 2004). „Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery”. J. Pharmacol. Exp. Ther. 309 (1): 137–45. DOI:10.1124/jpet.103.061192. PMID 14718590.
- ↑ Bexis S, Docherty JR (April 2009). „Role of alpha(1)- and beta(3)-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse”. British Journal of Pharmacology 158 (1): 259–66. DOI:10.1111/j.1476-5381.2009.00186.x. PMC 2795232. PMID 19422394.
