Muskarinski acetilholinski receptor M1

Izvor: Wikipedia
edit
Muskarinski acetilholinski receptor M1‎‎
Identifikatori
Simboli CHRM1; HM1; M1; M1R; MGC30125
Vanjski ID OMIM118510 MGI88396 HomoloGene20189 IUPHAR: M1 GeneCards: CHRM1 Gene
Ortolozi
Vrsta Čovek Miš
Entrez 1128 12669
Ensembl ENSG00000168539 ENSMUSG00000032773
UniProt P11229 Q52KQ0
RefSeq (mRNA) NM_000738 NM_007698
RefSeq (protein) NP_000729 NP_031724
Lokacija (UCSC) Chr 11:
62.68 - 62.69 Mb
Chr 19:
8.74 - 8.76 Mb
PubMed pretraga [1] [2]

Muskarinski acetilholinski receptor M1 (holinergički receptor, muskarinski 1) je muskarinski receptor.

Za ovaj receptor je nađeno da posreduje spori ekscitatorni postsinaptički potencijal u ganglionima postganglionskim nervima.[1] On je visoko zastupljen u eksokrinim žlezdama i u CNS-u.[2][3]

On se predominantno vezuje za Gq klasu G proteina,[4] koja stimuliše dejstvo fosfolipaze C i stoga inozitol trisfosfata i signalnog puta intracelularnog kalcijuma.

Efekti[uredi - уреди]

Mehanizam[uredi - уреди]

On formira spregu sa Gq, i u manjoj meri Gi i Gs. To dovodi do sporog EPSP i umanjene K+ provodnosti.[6][7]

Ligandi[uredi - уреди]

Agonisti

Alosterni modulatori

  • benzilhinolon karboksilna kiselina[8]
  • VU-0090157[9]
  • VU-0029767[9]

Antagonisti

Gen[uredi - уреди]

Ovaj receptor je kodiran humanim genom CHRM1.[5] On se nalazi na 11q13.[5]

Reference[uredi - уреди]

  1. Messer, Jr, WS (20. 1. 2000.). "Acetylcholine". University of Toledo. http://www.neurosci.pharm.utoledo.edu/MBC3320/acetylcholine.htm. pristupljeno 27. 10. 2007.. 
  2. Johnson, Gordon (2002). PDQ Pharmacology (2nd izd.). Hamilton, Ontario: BC Decker Inc. str. 311 pages. ISBN 1-55009-109-3. 
  3. Richelson, Elliott (2000). "Cholinergic Transduction, Psychopharmacology - The Fourth Generation of Progress". American College of Neuropsychopharmacology. http://www.acnp.org/g4/GN401000011/Default.htm. pristupljeno 27. 10. 2007.. 
  4. Burford NT, Nahorski SR (1996). "Muscarinic m1 receptor-stimulated adenylate cyclase activity in Chinese hamster ovary cells is mediated by Gs alpha and is not a consequence of phosphoinositidase C activation". Biochem. J. 315 (Pt 3): 883–8. PMID 8645172. 
  5. 5.0 5.1 5.2 5.3 "Entrez Gene: CHRM1 cholinergic receptor, muscarinic 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1128. 
  6. 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 6.9 Rang HP, Dale MM, Ritter JM, Moore PK (2003). "10". Pharmacology (5th izd.). Elsevier Churchill Livingstone. str. 139. ISBN 0-443-07145-4. 
  7. Uchimura N, North RA (1. 3. 1990.). "Muscarine reduces inwardly rectifying potassium conductance in rat nucleus accumbens neurones". J. Physiol. (Lond.) 422 (1): 369–80. PMID 1693682. 
  8. Shirey JK, Brady AE, Jones PJ, Davis AA, Bridges TM, Kennedy JP, Jadhav SB, Menon UN, Xiang Z, Watson ML, Christian EP, Doherty JJ, Quirk MC, Snyder DH, Lah JJ, Levey AI, Nicolle MM, Lindsley CW, Conn PJ (November 2009). "A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning". J. Neurosci. 29 (45): 14271–86. DOI:10.1523/JNEUROSCI.3930-09.2009. PMID 19906975. 
  9. 9.0 9.1 Marlo JE, Niswender CM, Days EL, et al. (2008). "Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity". Mol. Pharmacol. 75 (3): 577–88. DOI:10.1124/mol.108.052886. PMID 19047481. 

Literatura[uredi - уреди]

  • Rang HP, Dale MM, Ritter JM, Moore PK (2003). "10". Pharmacology (5th izd.). Elsevier Churchill Livingstone. str. 139. ISBN 0-443-07145-4. 
  • Johnson, Gordon (2002). PDQ Pharmacology (2nd izd.). Hamilton, Ontario: BC Decker Inc. str. 311 pages. ISBN 1-55009-109-3. 
  • Goyal RK (1989). "Muscarinic receptor subtypes. Physiology and clinical implications.". N. Engl. J. Med. 321 (15): 1022–9. DOI:10.1056/NEJM198910123211506. PMID 2674717. 
  • Brann MR, Ellis J, Jørgensen H, et al. (1994). "Muscarinic acetylcholine receptor subtypes: localization and structure/function.". Prog. Brain Res. 98: 121–7. DOI:10.1016/S0079-6123(08)62388-2. PMID 8248499. 
  • Nitsch RM, Slack BE, Wurtman RJ, Growdon JH (1992). "Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors.". Science 258 (5080): 304–7. DOI:10.1126/science.1411529. PMID 1411529. 
  • Arden JR, Nagata O, Shockley MS, et al. (1992). "Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the HM1 muscarinic receptor.". Biochem. Biophys. Res. Commun. 188 (3): 1111–5. DOI:10.1016/0006-291X(92)91346-R. PMID 1445347. 
  • Gutkind JS, Novotny EA, Brann MR, Robbins KC (1991). "Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.". Proc. Natl. Acad. Sci. U.S.A. 88 (11): 4703–7. DOI:10.1073/pnas.88.11.4703. PMID 1905013. 
  • Chapman CG, Browne MJ (1990). "Isolation of the human ml (Hml) muscarinic acetylcholine receptor gene by PCR amplification.". Nucleic Acids Res. 18 (8): 2191. DOI:10.1093/nar/18.8.2191. PMID 2336407. 
  • Ashkenazi A, Ramachandran J, Capon DJ (1989). "Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes.". Nature 340 (6229): 146–50. DOI:10.1038/340146a0. PMID 2739737. 
  • Bonner TI, Buckley NJ, Young AC, Brann MR (1987). "Identification of a family of muscarinic acetylcholine receptor genes.". Science 237 (4814): 527–32. DOI:10.1126/science.3037705. PMID 3037705. 
  • Peralta EG, Ashkenazi A, Winslow JW, et al. (1988). "Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.". EMBO J. 6 (13): 3923–9. PMID 3443095. 
  • Allard WJ, Sigal IS, Dixon RA (1988). "Sequence of the gene encoding the human M1 muscarinic acetylcholine receptor.". Nucleic Acids Res. 15 (24): 10604. DOI:10.1093/nar/15.24.10604. PMID 3697105. 
  • Svoboda P, Milligan G (1994). "Agonist-induced transfer of the alpha subunits of the guanine-nucleotide-binding regulatory proteins Gq and G11 and of muscarinic m1 acetylcholine receptors from plasma membranes to a light-vesicular membrane fraction.". Eur. J. Biochem. 224 (2): 455–62. DOI:10.1111/j.1432-1033.1994.00455.x. PMID 7925360. 
  • Crespo P, Xu N, Daniotti JL, et al. (1994). "Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway.". J. Biol. Chem. 269 (33): 21103–9. PMID 8063729. 
  • Russell M, Winitz S, Johnson GL (1994). "Acetylcholine muscarinic m1 receptor regulation of cyclic AMP synthesis controls growth factor stimulation of Raf activity.". Mol. Cell. Biol. 14 (4): 2343–51. PMID 8139539. 
  • Offermanns S, Wieland T, Homann D, et al. (1994). "Transfected muscarinic acetylcholine receptors selectively couple to Gi-type G proteins and Gq/11.". Mol. Pharmacol. 45 (5): 890–8. PMID 8190105. 
  • Mullaney I, Mitchell FM, McCallum JF, et al. (1993). "The human muscarinic M1 acetylcholine receptor, when express in CHO cells, activates and downregulates both Gq alpha and G11 alpha equally and non-selectively.". FEBS Lett. 324 (2): 241–5. DOI:10.1016/0014-5793(93)81401-K. PMID 8508928. 
  • Courseaux A, Grosgeorge J, Gaudray P, et al. (1997). "Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1).". Genomics 37 (3): 354–65. PMID 8938448. 
  • Ishiyama A, López I, Wackym PA (1998). "Molecular characterization of muscarinic receptors in the human vestibular periphery. Implications for pharmacotherapy.". The American journal of otology 18 (5): 648–54. PMID 9303164. 
  • Ishizaka N, Noda M, Yokoyama S, et al. (1998). "Muscarinic acetylcholine receptor subtypes in the human iris.". Brain Res. 787 (2): 344–7. DOI:10.1016/S0006-8993(97)01554-0. PMID 9518684. 
  • "Acetylcholine receptors (muscarinic): M1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2139. 

Vidi još[uredi - уреди]