FZD10
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| edit |
| Uvojiti receptor 10 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | FZD10; CD350; FZ-10; Fz10; FzE7; hFz10 | ||||||||||
| Vanjski ID | OMIM: 606147 MGI: 2136761 HomoloGene: 21411 IUPHAR: FZD10 GeneCards: FZD10 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 11211 | 93897 | |||||||||
| Ensembl | ENSG00000111432 | ENSMUSG00000081683 | |||||||||
| UniProt | Q9ULW2 | Q8BKG4 | |||||||||
| RefSeq (mRNA) | NM_007197.3 | NM_175284.3 | |||||||||
| RefSeq (protein) | NP_009128.1 | NP_780493.1 | |||||||||
| Lokacija (UCSC) | Chr 12: 130.65 - 130.65 Mb | Chr 5: 129.11 - 129.11 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Uvojiti-10 je protein koji je kod ljudi kodiran FZD10 genom.[1][2] FZD10 se takođe označava CD350 (klaster diferencijacije 350).
Članovi familije „uvojitih“ proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD10 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. Većina uvojitih receptora je spregnuta sa beta-kateninskim kanoničkim signalnim putem. Izražavanje ovog gena je znatno povećano ćelijama raka debelog creva.[2]
Reference[uredi | uredi kod]
- ↑ Koike J, Takagi A, Miwa T, Hirai M, Terada M, Katoh M (Sep 1999). „Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family”. Biochem Biophys Res Commun 262 (1): 39–43. DOI:10.1006/bbrc.1999.1161. PMID 10448064.
- ↑ 2,0 2,1 „Entrez Gene: FZD10 frizzled homolog 10 (Drosophila)”.
Literatura[uredi | uredi kod]
- Finch PW, He X, Kelley MJ, et al. (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. DOI:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
- Tanaka S, Akiyoshi T, Mori M, et al. (1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. DOI:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
- Kumar S, Connor JR, Dodds RA, et al. (2001). „Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries”. Osteoarthr. Cartil. 9 (7): 641–53. DOI:10.1053/joca.2001.0421. PMID 11597177.
- Terasaki H, Saitoh T, Shiokawa K, Katoh M (2002). „Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway”. Int. J. Mol. Med. 9 (2): 107–12. PMID 11786918.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Omoto S, Hayashi T, Kitahara K, et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”. Ophthalmic Genet. 25 (2): 81–90. DOI:10.1080/13816810490514270. PMID 15370539.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Vidi još[uredi | uredi kod]
Spoljašnje veze[uredi | uredi kod]
- „Frizzled Receptors: FZD10”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
- MeSH FZD10+protein,+human