Receptor insulinu sličnog faktora rasta 2

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Receptor insulinu sličnog faktora rasta 2‎

PDB prikaz baziran na 1e6f.
Dostupne strukture
1E6F, 1GP0, 1GP3, 1GQB, 1JWG, 1LF8, 2CNJ, 2L29, 2L2A, 2V5N, 2V5O, 2V5P
Identifikatori
Simboli IGF2R; CD222; CIMPR; M6P-R; MPR1; MPRI
Vanjski ID OMIM147280 MGI96435 HomoloGene676 GeneCards: IGF2R Gene
Pregled RNK izražavanja
PBB GE IGF2R 201393 s at tn.png
PBB GE IGF2R 201392 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 3482 16004
Ensembl ENSG00000197081 ENSMUSG00000023830
UniProt P11717 Q07113
RefSeq (mRNA) NM_000876.2 NM_010515.2
RefSeq (protein) NP_000867.2 NP_034645.2
Lokacija (UCSC) Chr 6:
160.39 - 160.53 Mb
Chr 17:
12.68 - 12.77 Mb
PubMed pretraga [1] [2]

Receptor insulinu sličnog faktora rasta 2 (IGF2R, katjionski nezavisni receptor manoza-6-fosfata, CI-MPR) je protein koji je kod ljudi kodiran IGF2R genom.[1][2] IGF2R je multifunkcionalni proteinski receptor za koji se vezuje insulinu sličan faktor rasta 2 (IGF2) na ćelijskoj površini i manoza-6-fosfat (M6P)-obeležene proteine u trans-Goldžijevom apararu.[2]

Interakcije[uredi - уреди]

Receptor insulinu sličnog faktora rasta 2 formira interakcije sa M6PRBP1.[3][4]

Reference[uredi - уреди]

  1. Oshima A, Nolan CM, Kyle JW, Grubb JH, Sly WS (February 1988). "The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells". J. Biol. Chem. 263 (5): 2553–62. PMID 2963003. 
  2. 2.0 2.1 Laureys G, Barton DE, Ullrich A, Francke U (October 1988). "Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse". Genomics 3 (3): 224–9. doi:10.1016/0888-7543(88)90083-3. PMID 2852162. 
  3. Díaz E, Pfeffer SR (May 1998). "TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking". Cell 93 (3): 433–43. doi:10.1016/S0092-8674(00)81171-X. PMID 9590177. 
  4. Orsel JG, Sincock PM, Krise JP, Pfeffer SR (August 2000). "Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9047–51. doi:10.1073/pnas.160251397. PMC 16819. PMID 10908666. 

Literatura[uredi - уреди]

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