Receptor insulinu sličnog faktora rasta 1

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Receptor insulinu sličnog faktora rasta 1‎‎

Prva tri domena receptora insulinu sličnog faktora rasta 1‎‎. PDB prikaz baziran na 1igr.
Dostupne strukture
1IGR, 1JQH, 1K3A, 1M7N, 1P4O, 2OJ9, 2ZM3, 3D94, 3F5P, 3I81, 3LVP, 3LW0, 3NW5, 3NW6, 3NW7, 3O23, 3QQU
Identifikatori
Simboli IGF1R; CD221; IGFIR; IGFR; JTK13
Vanjski ID OMIM147370 MGI96433 HomoloGene30997 GeneCards: IGF1R Gene
EC broj 2.7.10.1
Pregled RNK izražavanja
PBB GE IGF1R 203627 at tn.png
PBB GE IGF1R 203628 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 3480 16001
Ensembl ENSG00000140443 ENSMUSG00000005533
UniProt P08069 Q60751
RefSeq (mRNA) NM_000875.3 NM_010513.2
RefSeq (protein) NP_000866.1 NP_034643.2
Lokacija (UCSC) Chr 15:
99.19 - 99.51 Mb
Chr 7:
67.95 - 68.23 Mb
PubMed pretraga [1] [2]

Receptor insulinu sličnog faktora rasta 1 je protein koji je prisutan na površini ljudskih ćelija. On je transmembranski receptor koji se aktivira IGF-1 hormonom (insulinu sličan faktor rasta 1) i srodnim hormonom IGF-2. On pripada velikoj klasi tirozinsko kinaznih receptora . Ovaj receptor posreduje dejstvo IGF-1, koji je polipeptidni proteinski hormon sličan insulinu. IGF-1 utiče na razviće i nastavlja da vrši anaboličko dejstvo kod odraslih. On može da indukuje hipertroifju skeletalnih mišića i drugih ciljnih tkiva. Miševi bez IGF-1 receptora umiru u kasnijem periodu razvića, i manifestuju dramatičnu redukcu telesne mase, što potvrđuje jak uticaj ovog receptora. Miševi sa samo jednom funkcionalnom kopijom IGF1R su normalni, ali ispoljavaju ~15% umanjenje telesne mase.

Interakcije[uredi - уреди]

Receptor insulinu sličnog faktora rasta 1 formira interakcije sa SOCS3,[1] PTPN11,[2][3] SOCS2,[4] GRB10,[5][6][7][8] PIK3R3,[9] C-src tirosinska kinaza,[10] EHD1,[11] Cbl genom,[12] RAS p21 proteinskim aktivatorom 1,[3] IRS1,[2][6][13] ARHGEF12,[14] YWHAE,[15] Mdm2,[12] SHC1[6][13][16] i NEDD4.[5][12]

Regulacija[uredi - уреди]

Postoji evidencija da je IGF1R negativno regulisan dejstvom mikroRNK miR-7.[17]

References[uredi - уреди]

  1. Dey, B R; Furlanetto R W, Nissley P (November 2000). "Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor". Biochem. Biophys. Res. Commun. (UNITED STATES) 278 (1): 38–43. doi:10.1006/bbrc.2000.3762. ISSN 0006-291X. PMID 11071852. 
  2. 2.0 2.1 Mañes, S; Mira E, Gómez-Mouton C, Zhao Z J, Lacalle R A, Martínez-A C (April 1999). "Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility". Mol. Cell. Biol. (UNITED STATES) 19 (4): 3125–35. ISSN 0270-7306. PMC 84106. PMID 10082579. 
  3. 3.0 3.1 Seely, B L; Reichart D R, Staubs P A, Jhun B H, Hsu D, Maegawa H, Milarski K L, Saltiel A R, Olefsky J M (August 1995). "Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein". J. Biol. Chem. (UNITED STATES) 270 (32): 19151–7. doi:10.1074/jbc.270.32.19151. ISSN 0021-9258. PMID 7642582. 
  4. Dey, B R; Spence S L, Nissley P, Furlanetto R W (September 1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor". J. Biol. Chem. (UNITED STATES) 273 (37): 24095–101. doi:10.1074/jbc.273.37.24095. ISSN 0021-9258. PMID 9727029. 
  5. 5.0 5.1 Vecchione, Andrea; Marchese Adriano, Henry Pauline, Rotin Daniela, Morrione Andrea (May. 2003). "The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor". Mol. Cell. Biol. (United States) 23 (9): 3363–72. doi:10.1128/MCB.23.9.3363-3372.2003. ISSN 0270-7306. PMC 153198. PMID 12697834. 
  6. 6.0 6.1 6.2 Dey, B R; Frick K, Lopaczynski W, Nissley S P, Furlanetto R W (June 1996). "Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10". Mol. Endocrinol. (UNITED STATES) 10 (6): 631–41. doi:10.1210/me.10.6.631. ISSN 0888-8809. PMID 8776723. 
  7. He, W; Rose D W, Olefsky J M, Gustafson T A (March 1998). "Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains". J. Biol. Chem. (UNITED STATES) 273 (12): 6860–7. doi:10.1074/jbc.273.12.6860. ISSN 0021-9258. PMID 9506989. 
  8. Morrione, A; Valentinis B, Li S, Ooi J Y, Margolis B, Baserga R (July 1996). "Grb10: A new substrate of the insulin-like growth factor I receptor". Cancer Res. (UNITED STATES) 56 (14): 3165–7. ISSN 0008-5472. PMID 8764099. 
  9. Mothe, I; Delahaye L, Filloux C, Pons S, White M F, Van Obberghen E (December 1997). "Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins". Mol. Endocrinol. (UNITED STATES) 11 (13): 1911–23. doi:10.1210/me.11.13.1911. ISSN 0888-8809. PMID 9415396. 
  10. Arbet-Engels, C; Tartare-Deckert S, Eckhart W (February 1999). "C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor". J. Biol. Chem. (UNITED STATES) 274 (9): 5422–8. doi:10.1074/jbc.274.9.5422. ISSN 0021-9258. PMID 10026153. 
  11. Rotem-Yehudar, R; Galperin E, Horowitz M (August 2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29". J. Biol. Chem. (United States) 276 (35): 33054–60. doi:10.1074/jbc.M009913200. ISSN 0021-9258. PMID 11423532. 
  12. 12.0 12.1 12.2 Sehat, Bita; Andersson Sandra, Girnita Leonard, Larsson Olle (July 2008). "Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis". Cancer Res. (United States) 68 (14): 5669–77. doi:10.1158/0008-5472.CAN-07-6364. PMID 18632619. 
  13. 13.0 13.1 Tartare-Deckert, S; Sawka-Verhelle D, Murdaca J, Van Obberghen E (October 1995). "Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system". J. Biol. Chem. (UNITED STATES) 270 (40): 23456–60. doi:10.1074/jbc.270.40.23456. ISSN 0021-9258. PMID 7559507. 
  14. Taya, S; Inagaki N, Sengiku H, Makino H, Iwamatsu A, Urakawa I, Nagao K, Kataoka S, Kaibuchi K (November 2001). "Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF". J. Cell Biol. (United States) 155 (5): 809–20. doi:10.1083/jcb.200106139. ISSN 0021-9525. PMC 2150867. PMID 11724822. 
  15. Craparo, A; Freund R, Gustafson T A (April 1997). "14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner". J. Biol. Chem. (UNITED STATES) 272 (17): 11663–9. doi:10.1074/jbc.272.17.11663. ISSN 0021-9258. PMID 9111084. 
  16. Santen, R J; Song R X, Zhang Z, Kumar R, Jeng M-H, Masamura A, Lawrence J, Berstein L, Yue W (July 2005). "Long-term estradiol deprivation in breast cancer cells up-regulates growth factor signaling and enhances estrogen sensitivity". Endocr. Relat. Cancer. 12 (England). Suppl 1 (Supplement_1): S61–73. doi:10.1677/erc.1.01018. ISSN 1351-0088. PMID 16113100. 
  17. Jiang, Lu; Liu, Xiqiang; Chen, Zujian; Jin, Yi; Heidbreder, Caroline E.; Kolokythas, Antonia; Wang, Anxun; Dai, Yang et al. (2010). "MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells". Biochemical Journal 432 (1): 199–205. doi:10.1042/BJ20100859. PMID 20819078. 

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