GPR6

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G protein-spregnuti receptor 6
Identifikatori
Simboli GPR6;
Vanjski ID OMIM600553 MGI2155249 HomoloGene38026 IUPHAR: GPR6 GeneCards: GPR6 Gene
Pregled RNK izražavanja
PBB GE GPR6 214655 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2830 140741
Ensembl ENSG00000146360 ENSMUSG00000046922
UniProt P46095 Q2M2N8
RefSeq (mRNA) NM_005284 NM_199058
RefSeq (protein) NP_005275 NP_951013
Lokacija (UCSC) Chr 6:
110.41 - 110.41 Mb
Chr 10:
40.76 - 40.76 Mb
PubMed pretraga [1] [2]

GPR6, G protein-spregnuti receptor 6, je protein koji je kod čoveka kodiran GPR6 genom.[1][2]

Funkcija[uredi - уреди]

GPR6 je član familije GPCR transmembranskih receptora. Postoje tvrdnje da je GPR6 konstitutivno aktivan, i da se dodatno aktivira sfingozin-1-fosfatom.[3]

GPR6 povišava nivoe cikličnog AMP i promoviše rast neurita.[4]

Vidi još[uredi - уреди]

Literatura[uredi - уреди]

  1. "Entrez Gene: GPR6 G protein-coupled receptor 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2830. 
  2. Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049. 
  3. Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cellular Signalling 14 (11): 941–53. doi:10.1016/S0898-6568(02)00041-4. PMID 12220620. 
  4. Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (April 2007). "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth". The Journal of Biological Chemistry 282 (14): 10506–15. doi:10.1074/jbc.M700911200. PMID 17284443. 

Dodatna literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]