GPR6

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G protein-spregnuti receptor 6
Identifikatori
Simboli GPR6;
Vanjski ID OMIM600553 MGI2155249 HomoloGene38026 IUPHAR: GPR6 GeneCards: GPR6 Gene
Pregled RNK izražavanja
PBB GE GPR6 214655 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2830 140741
Ensembl ENSG00000146360 ENSMUSG00000046922
UniProt P46095 Q2M2N8
RefSeq (mRNA) NM_005284 NM_199058
RefSeq (protein) NP_005275 NP_951013
Lokacija (UCSC) Chr 6:
110.41 - 110.41 Mb
Chr 10:
40.76 - 40.76 Mb
PubMed pretraga [1] [2]

GPR6, G protein-spregnuti receptor 6, je protein koji je kod čoveka kodiran GPR6 genom.[1][2]

Funkcija[uredi - уреди]

GPR6 je član familije GPCR transmembranskih receptora. Postoje tvrdnje da je GPR6 konstitutivno aktivan, i da se dodatno aktivira sfingozin-1-fosfatom.[3]

GPR6 povišava nivoe cikličnog AMP i promoviše rast neurita.[4]

Vidi još[uredi - уреди]

Literatura[uredi - уреди]

  1. "Entrez Gene: GPR6 G protein-coupled receptor 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2830. 
  2. Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics 28 (2): 347–9. DOI:10.1006/geno.1995.1154. PMID 8530049. 
  3. Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cellular Signalling 14 (11): 941–53. DOI:10.1016/S0898-6568(02)00041-4. PMID 12220620. 
  4. Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (April 2007). "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth". The Journal of Biological Chemistry 282 (14): 10506–15. DOI:10.1074/jbc.M700911200. PMID 17284443. 

Dodatna literatura[uredi - уреди]

  • Heiber M, Docherty JM, Shah G, et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors.". DNA Cell Biol. 14 (1): 25–35. DOI:10.1089/dna.1995.14.25. PMID 7832990. 
  • Song ZH, Modi W, Bonner TI (1996). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.". Genomics 28 (2): 347–9. DOI:10.1006/geno.1995.1154. PMID 8530049. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMID 12477932. 
  • Uhlenbrock K, Huber J, Ardati A, et al. (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells.". Cell. Physiol. Biochem. 13 (2): 75–84. DOI:10.1159/000070251. PMID 12649592. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. DOI:10.1038/nature02055. PMID 14574404. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMID 15489334. 

Spoljašnje veze[uredi - уреди]