GPR50
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| G protein-spregnuti receptor 50 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | GPR50; H9; MGC125342 | ||||||||||
| Vanjski ID | OMIM: 300207 MGI: 1333877 HomoloGene: 3113 IUPHAR: GPR50 GeneCards: GPR50 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 9248 | 14765 | |||||||||
| Ensembl | ENSG00000102195 | ENSMUSG00000056380 | |||||||||
| UniProt | Q13585 | Q3V1S8 | |||||||||
| RefSeq (mRNA) | NM_004224 | XM_990925 | |||||||||
| RefSeq (protein) | NP_004215 | XP_996019 | |||||||||
| Lokacija (UCSC) | Chr X: 150.1 - 150.1 Mb | Chr X: 67.92 - 67.93 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
GPR50, G protein-spregnuti receptor 50, je protein koji je kod čoveka kodiran GPR50 genom.[1][2][3]
Funkcija[uredi | uredi kod]
GPR50 je član GPCR familije integralnih membranskih proteina. On je sličan melatoninskom receptoru.[2] GPR50 ima sposobnost formiranja heterodimera sa MT1 i MT2 melatoninskim receptorima. Dok GPR50 nema uticaja na MT2 funkciju, on sprečava MT1 da veže melatonin i formira kompleks sa G proteinima.[4]
Klinički značaj[uredi | uredi kod]
Određeni polimorfizmi GPR50 gena kod žena su povezani sa povišenim rizikom razvoja bipolarnog poremećaja, kliničkom depresijom, i šizofrenijom.[5] Drugi GPR50 genski polimorfizmi uslovljavaju povišenje nivoa cirkulišućih triglicerida i sniženje nivoa cirkulišućih lipoproteina visoke gustine.[6]
Literatura[uredi | uredi kod]
- ↑ „Entrez Gene: GPR50 G protein-coupled receptor 50”.
- ↑ 2,0 2,1 Reppert SM, Weaver DR, Ebisawa T, Mahle CD, Kolakowski LF (May 1996). „Cloning of a melatonin-related receptor from human pituitary”. FEBS letters 386 (2-3): 219–24. DOI:10.1016/0014-5793(96)00437-1. PMID 8647286.
- ↑ Gubitz AK, Reppert SM (January 1999). „Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)”. Genomics 55 (2): 248–51. DOI:10.1006/geno.1998.5661. PMID 9933574.
- ↑ Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R (July 2006). „The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization”. The EMBO journal 25 (13): 3012–23. DOI:10.1038/sj.emboj.7601193. PMC 1500982. PMID 16778767.
- ↑ Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ (May 2005). „Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor”. Molecular psychiatry 10 (5): 470–8. DOI:10.1038/sj.mp.4001593. PMID 15452587.
- ↑ Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S (April 2006). „Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels”. Journal of lipid research 47 (4): 761–6. DOI:10.1194/jlr.M500338-JLR200. PMID 16436372.
Dodatna literatura[uredi | uredi kod]
- Reppert SM, Weaver DR, Ebisawa T, et al. (1996). „Cloning of a melatonin-related receptor from human pituitary.”. FEBS Lett. 386 (2-3): 219–24. DOI:10.1016/0014-5793(96)00437-1. PMID 8647286.
- Gubitz AK, Reppert SM (1999). „Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50).”. Genomics 55 (2): 248–51. DOI:10.1006/geno.1998.5661. PMID 9933574.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Slominski A, Pisarchik A, Zbytek B, et al. (2003). „Functional activity of serotoninergic and melatoninergic systems expressed in the skin.”. J. Cell. Physiol. 196 (1): 144–53. DOI:10.1002/jcp.10287. PMID 12767050.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). „Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.”. Genome Res. 14 (9): 1711–8. DOI:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Thomson PA, Wray NR, Thomson AM, et al. (2005). „Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor.”. Mol. Psychiatry 10 (5): 470–8. DOI:10.1038/sj.mp.4001593. PMID 15452587.
- Bhattacharyya S, Luan J, Challis B, et al. (2006). „Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels.”. J. Lipid Res. 47 (4): 761–6. DOI:10.1194/jlr.M500338-JLR200. PMID 16436372.
- Levoye A, Dam J, Ayoub MA, et al. (2006). „The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization.”. EMBO J. 25 (13): 3012–23. DOI:10.1038/sj.emboj.7601193. PMC 1500982. PMID 16778767.