Neuropeptidni Y receptor Y1

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Neuropeptidni Y receptor Y1
Identifikatori
Simboli	NPY1R; NPYR
Vanjski ID	OMIM: 162641 MGI: 104963 HomoloGene: 700 IUPHAR: Y1 GeneCards: NPY1R Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu-sličnog receptora • aktivnost peptidnog YY receptora • aktivnost pankreasnog polipeptidnog receptora • receptorska aktivnost • aktivnost neuropeptidnog Y receptora • proteinsko vezivanje Celularna komponenta • integralno sa ćelijskom membranom • membrana • integralno sa membranom Biološki proces • glukozni metabolički proces • prenos signala • G-protein signalizacija, spregnuta sa cikličnim nukleotidnim sekundarnim glasnikom • G-proteinska signalizacija, put inhibicije adenilat ciklaze • neuropeptidni signalni put • lokomotorno ponašanje • način ishrane • regulacija krvnog pritiska • senzorna percepcija bola • regulacija veličine tela
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	4886	18166
Ensembl	ENSG00000164128	ENSMUSG00000036437
UniProt	P25929	Q3V1K5
RefSeq (mRNA)	NM_000909	NM_010934
RefSeq (protein)	NP_000900	NP_035064
Lokacija (UCSC)	Chr 4: 164.46 - 164.47 Mb	Chr 8: 69.63 - 69.64 Mb
PubMed pretraga	[1]	[2]

Neuropeptidni Y receptor tip 1 je protein koji je kod ljudi kodiran NPY1R genom.

Selektivni ligandi

Agonisti

• Neuropeptid Y (endogeni agonist)
• Peptid YY

Antagonisti

Peptid

• BVD-10 (selektivni NPY₁ antagonist)
• GR-231,118 (mešoviti NPY₁ antagonist / NPY₄ agonist)

Ne-peptid

• BIBO-3304
• BIBP-3226
• PD-160,170

Vidi još

• Neuropeptidni Y receptor

Literatura

• Wan CP, Lau BH (1997). „Neuropeptide Y receptor subtypes.”. Life Sci. 56 (13): 1055–64. DOI:10.1016/0024-3205(95)00041-4. PMID 9001438. 
• Parker E, Van Heek M, Stamford A (2002). „Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.”. Eur. J. Pharmacol. 440 (2-3): 173–87. DOI:10.1016/S0014-2999(02)01427-9. PMID 12007534. 
• Bettio A, Beck-Sickinger AG (2002). „Biophysical methods to study ligand-receptor interactions of neuropeptide Y.”. Biopolymers 60 (6): 420–37. DOI:10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W. PMID 12209475. 
• Larhammar D, Blomqvist AG, Yee F, et al. (1992). „Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type.”. J. Biol. Chem. 267 (16): 10935–8. PMID 1317848. 
• Herzog H, Hort YJ, Ball HJ, et al. (1992). „Cloned human neuropeptide Y receptor couples to two different second messenger systems.”. Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5794–8. DOI:10.1073/pnas.89.13.5794. PMC 402104. PMID 1321422. 
• Rose PM, Fernandes P, Lynch JS, et al. (1995). „Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor.”. J. Biol. Chem. 270 (39): 22661–4. DOI:10.1074/jbc.270.39.22661. PMID 7559383. 
• Gicquiaux H, Lecat S, Gaire M, et al. (2002). „Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor.”. J. Biol. Chem. 277 (8): 6645–55. DOI:10.1074/jbc.M107224200. PMID 11741903. 
• Sheriff S, F Qureshy A, T Chance W, et al. (2002). „Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected].”. Peptides 23 (1): 87–96. DOI:10.1016/S0196-9781(01)00583-6. PMID 11814622. 
• Cox HM, Tough IR (2002). „Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa.”. Br. J. Pharmacol. 135 (6): 1505–12. DOI:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964. 
• Uddman R, Möller S, Nilsson T, et al. (2003). „Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues.”. Peptides 23 (5): 927–34. DOI:10.1016/S0196-9781(02)00003-7. PMID 12084524. 
• Cantó Soler MV, Gallo JE, Dodds RA, et al. (2002). „Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina.”. Glia 39 (3): 320–4. DOI:10.1002/glia.10107. PMID 12203398. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Berglund MM, Schober DA, Statnick MA, et al. (2003). „The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction.”. J. Pharmacol. Exp. Ther. 306 (1): 147–56. DOI:10.1124/jpet.103.051227. PMID 12665544. 
• Lehner B, Sanderson CM (2004). „A protein interaction framework for human mRNA degradation.”. Genome Res. 14 (7): 1315–23. DOI:10.1101/gr.2122004. PMC 442147. PMID 15231747. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Körner M, Waser B, Reubi JC (2005). „High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia.”. Clin. Cancer Res. 10 (24): 8426–33. DOI:10.1158/1078-0432.CCR-04-0821. PMID 15623622. 

Spoljašnje veze

• „Neuropeptide Y Receptors: Y₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.