CP-154,526

Izvor: Wikipedia
CP-154,526
CP154526.svg
IUPAC ime
Identifikacija
CAS registarski broj 157286-86-7
PubChem[1][2] 5311055
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C23H32N4
Molarna masa 364.53 g mol−1

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

CP-154,526 je potentan i selektivan antagonist Kortikotropin-oslobađajućeg hormonskog receptor 1 koji je razvila kompanija Pfizer.[3]

CP-154,526 se ispituje za moguću upotrebu u lečenju alkoholizma.[4][5]

Vidi još[uredi - уреди]

Literatura[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Schulz DW, Mansbach RS, Sprouse J, Braselton JP, Collins J, Corman M, Dunaiskis A, Faraci S, Schmidt AW, Seeger T, Seymour P, Tingley FD 3rd, Winston EN, Chen YL, Heym J (September 1996). "CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10477–82. doi:10.1073/pnas.93.19.10477. PMC 38410. PMID 8816826. 
  4. "Drug Has Potential To Prevent Alcoholics From Relapsing". Science News. ScienceDaily. 2. 8. 2008.. http://www.sciencedaily.com/releases/2008/07/080730175518.htm. pristupljeno 9. 8. 2008.. 
  5. Pastor R, McKinnon CS, Scibelli AC, Burkhart-Kasch S, Reed C, Ryabinin AE, Coste SC, Stenzel-Poore MP, Phillips TJ (July 2008). "Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism". Proc. Natl. Acad. Sci. U.S.A. 105 (26): 9070–5. doi:10.1073/pnas.0710181105. PMC 2449366. PMID 18591672. 

Spoljašnje veze[uredi - уреди]


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