FZD1
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| edit |
| Uvojiti receptor 1 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | FZD1; DKFZp564G072; FLJ95923 | ||||||||||
| Vanjski ID | OMIM: 603408 MGI: 1196625 HomoloGene: 20750 IUPHAR: FZD1 GeneCards: FZD1 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 8321 | 14362 | |||||||||
| Ensembl | ENSG00000157240 | ENSMUSG00000044674 | |||||||||
| UniProt | Q9UP38 | O70421 | |||||||||
| RefSeq (mRNA) | NM_003505.1 | NM_021457.3 | |||||||||
| RefSeq (protein) | NP_003496.1 | NP_067432.2 | |||||||||
| Lokacija (UCSC) | Chr 7: 90.89 - 90.9 Mb | Chr 5: 4.75 - 4.76 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Uvojiti-1 je protein koji je kod ljudi kodiran FZD1 genom.[1][2]
Članovi familije 'uvojitih' proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD1 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. FZD1 transkript je izražen u različitim tkivima.[2]
Reference[uredi | uredi kod]
- ↑ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Dec 1998). „Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7”. Biochem Biophys Res Commun 252 (1): 117–22. DOI:10.1006/bbrc.1998.9607. PMID 9813155.
- ↑ 2,0 2,1 „Entrez Gene: FZD1 frizzled homolog 1 (Drosophila)”.
Literatura[uredi | uredi kod]
- Tanaka S, Akiyoshi T, Mori M, et al. (1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. DOI:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
- Gazit A, Yaniv A, Bafico A, et al. (1999). „Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.”. Oncogene 18 (44): 5959–66. DOI:10.1038/sj.onc.1202985. PMID 10557084.
- DeCostanzo AJ, Huang XP, Wang HY, Malbon CC (2002). „The Frizzled-1/(beta(2))-adrenergic receptor chimera: pharmacological properties of a unique G protein-linked receptor.”. Naunyn Schmiedebergs Arch. Pharmacol. 365 (5): 341–8. DOI:10.1007/s00210-002-0540-3. PMID 12012019.
- Hering H, Sheng M (2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.”. FEBS Lett. 521 (1–3): 185–9. DOI:10.1016/S0014-5793(02)02831-4. PMID 12067714.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). „Human chromosome 7: DNA sequence and biology”. Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). „The DNA sequence of human chromosome 7”. Nature 424 (6945): 157–64. DOI:10.1038/nature01782. PMID 12853948.
- Zilberberg A, Yaniv A, Gazit A (2004). „The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway”. J. Biol. Chem. 279 (17): 17535–42. DOI:10.1074/jbc.M311292200. PMID 14739301.
- Wu J, Klein TJ, Mlodzik M (2006). „Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity”. PLoS Biol. 2 (7): E158. DOI:10.1371/journal.pbio.0020158. PMC 449784. PMID 15252441.
- Omoto S, Hayashi T, Kitahara K, et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”. Ophthalmic Genet. 25 (2): 81–90. DOI:10.1080/13816810490514270. PMID 15370539.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Yang L, Yamasaki K, Shirakata Y, et al. (2006). „Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes”. J. Dermatol. Sci. 42 (2): 111–9. DOI:10.1016/j.jdermsci.2005.12.011. PMID 16442268.
Vidi još[uredi | uredi kod]
Spoljašnje veze[uredi | uredi kod]
- „Frizzled Receptors: FZD1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.