Galaninski receptor 2

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Galaninski receptor 2
Identifikatori
Simboli GALR2; GALNR2; MGC125983; MGC125984
Vanjski ID OMIM603691 MGI1337018 HomoloGene2863 IUPHAR: GAL2 GeneCards: GALR2 Gene
Pregled RNK izražavanja
PBB GE GALR2 211226 at tn.png
PBB GE GALR2 gnf1h09841 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 8811 14428
Ensembl ENSG00000182687 ENSMUSG00000020793
UniProt O43603 Q14A53
RefSeq (mRNA) NM_003857 NM_010254
RefSeq (protein) NP_003848 NP_034384
Lokacija (UCSC) Chr 17:
71.58 - 71.59 Mb
Chr 11:
116.1 - 116.1 Mb
PubMed pretraga [1] [2]

Galaninski receptor 2, (GAL2) je G protein spregnuti receptor kodiran GALR2 genom.[1]

Galanin je važan neuromodulator prisutan u mozgu, gastrointestinalnom sistemu, i hipotalamo-hipofiznoj osi. To je peptid sa 30 aminokiselina koji nije C-terminalno amidiran. On potentno stimuliše sekreciju hormona rasta, usporava brzinu srca, ukida sinusnu aritmiju, i inhibira gastrointestinalni motilitet nakon obroka. Dejstvo galanina je posredovano kroz interakciju sa specifičnim membranskim receptorima koji su članovi 7-transmembranske familije G protein-spregnutih receptora. GALR2 interaguje sa N-terminalnim ostacima galanina. Primarni signalni mehanizam GALR2 receptora je put fosfolipaze C/protein kinaze C (preko Gq), u kontrastu sa GALR1, koji prenosi svoj signal inhibicijom adenilat ciklaze kroz Gi. Bilo je pokazano da se GALR2 efektivno spreže sa Gq i Gi proteinima, i da može da simultano aktivira dva nezavisna puta prenosa signala.[1]

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Reference[uredi - уреди]

Literatura[uredi - уреди]

  • Bloomquist BT, Beauchamp MR, Zhelnin L, et al. (1998). "Cloning and expression of the human galanin receptor GalR2.". Biochem. Biophys. Res. Commun. 243 (2): 474–9. DOI:10.1006/bbrc.1998.8133. PMID 9480833. 
  • Fathi Z, Battaglino PM, Iben LG, et al. (1998). "Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.". Brain Res. Mol. Brain Res. 58 (1-2): 156–69. DOI:10.1016/S0169-328X(98)00116-8. PMID 9685625. 
  • Kolakowski LF, O'Neill GP, Howard AD, et al. (1998). "Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.". J. Neurochem. 71 (6): 2239–51. DOI:10.1046/j.1471-4159.1998.71062239.x. PMID 9832121. 
  • Borowsky B, Walker MW, Huang LY, et al. (1999). "Cloning and characterization of the human galanin GALR2 receptor.". Peptides 19 (10): 1771–81. DOI:10.1016/S0196-9781(98)00133-8. PMID 9880084. 
  • Berger A, Tuechler C, Almer D, et al. (2002). "Elevated expression of galanin receptors in childhood neuroblastic tumors.". Neuroendocrinology 75 (2): 130–8. DOI:10.1159/000048229. PMID 11867941. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMID 12477932. 
  • Berger A, Lang R, Moritz K, et al. (2004). "Galanin receptor subtype GalR2 mediates apoptosis in SH-SY5Y neuroblastoma cells.". Endocrinology 145 (2): 500–7. DOI:10.1210/en.2003-0649. PMID 14592962. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMID 15489334. 
  • Belfer I, Hipp H, Bollettino A, et al. (2007). "Alcoholism is associated with GALR3 but not two other galanin receptor genes.". Genes, Brain and Behavior 6 (5): 473–81. DOI:10.1111/j.1601-183X.2006.00275.x. PMID 17083333. 

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