TAS2R38

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Receptor ukusa tip 2 član 38
Identifikatori
Simboli TAS2R38; PTC; T2R38; T2R61
Vanjski ID OMIM607751 MGI2681306 HomoloGene47976 IUPHAR: GeneCards: TAS2R38 Gene
Ortolozi
Vrsta Čovek Miš
Entrez 5726 387513
Ensembl ENSG00000257138 ENSMUSG00000058250
UniProt P59533 Q7TQA6
RefSeq (mRNA) NM_176817.4 NM_001001451.1
RefSeq (protein) NP_789787.4 NP_001001451.1
Lokacija (UCSC) Chr 7:
141.67 - 141.67 Mb
Chr 6:
40.56 - 40.56 Mb
PubMed pretraga [1] [2]

Receptor ukusa tip 2 član 38 je protein koji je kod ljudi kodiran TAS2R38 genom. TAS2R38 je receptor gorkog ukusa. Različiti genotipi ovog receptora utiču na sposobnost prepoznavanja ukusa 6-n-propiltiouracila (PROP)[1] i feniltiokarbamida (PTC).[2][3] Though it has often been proposed that varying taste receptor genotypes could influence tasting ability, TAS2R38 is one of the only taste receptors shown to have this function.[4]

Prenos signala[uredi - уреди]

Kao i kod svih TAS2R proteina, TAS2R38 koristi G-protein gustducin kao svoj primarni metod prenosa signala. Jedinice α i βγ su esencijalne za prenos signala ukusa.[5]

Reference[uredi - уреди]

  1. Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM (2004). "Bitter Receptor Gene (TAS2R38), 6-n-Propylthiouracil (PROP) Bitterness and Alcohol Intake". Alcoholism, clinical and experimental research 28 (11): 1629–1637. DOI:10.1097/01.ALC.0000145789.55183.D4. PMID 15547448. 
  2. Prodi DA, Drayna D, Forabosco P, Palmas MA, Maestrale GB, Piras D, Pirastu M, Angius A (2004). "Bitter Taste Study in a Sardinian Genetic Isolate Supports the Association of Phenylthiocarbamide Sensitivity to the TAS2R38 Bitter Receptor Gene". Chemical Senses 29 (8): 697–702. DOI:10.1093/chemse/bjh074. PMID 15466815. 
  3. Kim UK, Drayna D (2004). "Genetics of individual differences in bitter taste perception: Lessons from the PTC gene". Clinical Genetics 67 (4): 275–280. DOI:10.1111/j.1399-0004.2004.00361.x. PMID 15733260. 
  4. Bachmanov AA, Beauchamp GK (2007). "Taste Receptor Genes". Annual Review of Nutrition 27: 389–414. DOI:10.1146/annurev.nutr.26.061505.111329. PMID 17444812. 
  5. Margolskee RF (2001). "Molecular Mechanisms of Bitter and Sweet Taste Transduction". Journal of Biological Chemistry 277 (1): 1–4. DOI:10.1074/jbc.R100054200. PMID 11696554. 

Literatura[uredi - уреди]

  • Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. DOI:10.1016/S0959-4388(02)00345-8. PMID 12139982. 
  • Anne-Spence M, Falk CT, Neiswanger K, et al. (1984). "Estimating the recombination frequency for the PTC-Kell linkage". Hum. Genet. 67 (2): 183–6. DOI:10.1007/BF00272997. PMID 6745938. 
  • Bufe B, Hofmann T, Krautwurst D, et al. (2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat. Genet. 32 (3): 397–401. DOI:10.1038/ng1014. PMID 12379855. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMID 12477932. 
  • Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell 112 (3): 293–301. DOI:10.1016/S0092-8674(03)00071-0. PMID 12581520. 
  • Conte C, Ebeling M, Marcuz A, et al. (2003). "Identification and characterization of human taste receptor genes belonging to the TAS2R family". Cytogenet. Genome Res. 98 (1): 45–53. DOI:10.1159/000068546. PMID 12584440. 
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMID 12690205. 
  • Pronin AN, Tang H, Connor J, Keung W (2005). "Identification of ligands for two human bitter T2R receptors". Chem. Senses 29 (7): 583–93. DOI:10.1093/chemse/bjh064. PMID 15337684. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMID 15489334. 
  • Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. DOI:10.1093/molbev/msi027. PMID 15496549. 
  • Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates". Genetics 170 (1): 313–26. DOI:10.1534/genetics.104.037523. PMID 15744053. 

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