TAS2R38

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Receptor ukusa tip 2 član 38
Identifikatori
Simboli TAS2R38; PTC; T2R38; T2R61
Vanjski ID OMIM607751 MGI2681306 HomoloGene47976 IUPHAR: GeneCards: TAS2R38 Gene
Ortolozi
Vrsta Čovek Miš
Entrez 5726 387513
Ensembl ENSG00000257138 ENSMUSG00000058250
UniProt P59533 Q7TQA6
RefSeq (mRNA) NM_176817.4 NM_001001451.1
RefSeq (protein) NP_789787.4 NP_001001451.1
Lokacija (UCSC) Chr 7:
141.67 - 141.67 Mb
Chr 6:
40.56 - 40.56 Mb
PubMed pretraga [1] [2]

Receptor ukusa tip 2 član 38 je protein koji je kod ljudi kodiran TAS2R38 genom. TAS2R38 je receptor gorkog ukusa. Različiti genotipi ovog receptora utiču na sposobnost prepoznavanja ukusa 6-n-propiltiouracila (PROP)[1] i feniltiokarbamida (PTC).[2][3] Though it has often been proposed that varying taste receptor genotypes could influence tasting ability, TAS2R38 is one of the only taste receptors shown to have this function.[4]

Prenos signala[uredi - уреди]

Kao i kod svih TAS2R proteina, TAS2R38 koristi G-protein gustducin kao svoj primarni metod prenosa signala. Jedinice α i βγ su esencijalne za prenos signala ukusa.[5]

Reference[uredi - уреди]

  1. Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM (2004). "Bitter Receptor Gene (TAS2R38), 6-n-Propylthiouracil (PROP) Bitterness and Alcohol Intake". Alcoholism, clinical and experimental research 28 (11): 1629–1637. doi:10.1097/01.ALC.0000145789.55183.D4. PMC 1397913. PMID 15547448. 
  2. Prodi DA, Drayna D, Forabosco P, Palmas MA, Maestrale GB, Piras D, Pirastu M, Angius A (2004). "Bitter Taste Study in a Sardinian Genetic Isolate Supports the Association of Phenylthiocarbamide Sensitivity to the TAS2R38 Bitter Receptor Gene". Chemical Senses 29 (8): 697–702. doi:10.1093/chemse/bjh074. PMID 15466815. 
  3. Kim UK, Drayna D (2004). "Genetics of individual differences in bitter taste perception: Lessons from the PTC gene". Clinical Genetics 67 (4): 275–280. doi:10.1111/j.1399-0004.2004.00361.x. PMID 15733260. 
  4. Bachmanov AA, Beauchamp GK (2007). "Taste Receptor Genes". Annual Review of Nutrition 27: 389–414. doi:10.1146/annurev.nutr.26.061505.111329. PMC 2721271. PMID 17444812. 
  5. Margolskee RF (2001). "Molecular Mechanisms of Bitter and Sweet Taste Transduction". Journal of Biological Chemistry 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554. 

Literatura[uredi - уреди]

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