Histaminski H2 receptor

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Histaminski receptor H2
Identifikatori
Simboli HRH2; H2R
Vanjski ID OMIM142703 MGI108482 HomoloGene40613 IUPHAR: H2 GeneCards: HRH2 Gene
Pregled RNK izražavanja
PBB GE HRH2 220805 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 3274 15466
Ensembl ENSG00000113749 ENSMUSG00000034987
UniProt P25021 Q3ZB30
RefSeq (mRNA) NM_001131055.1 NM_001010973.2
RefSeq (protein) NP_001124527.1 NP_001010973.1
Lokacija (UCSC) Chr 5:
175.09 - 175.11 Mb
Chr 13:
54.29 - 54.32 Mb
PubMed pretraga [1] [2]

H2 receptori su pozitivno spregnut sa adenilat ciklazom preko Gs. H2 receptor je potentan stimulans cAMP produkcije. On povišava intraćelijske Ca2+ koncentracije i oslobađanje Ca2+ iz intraćelijskih zaliha. Lek betazol je primer agonista histaminskog H2 receptora.

Funkcija[uredi - уреди]

Histamin je sveprisutni molekulski glasnik koji se otpušta iz mastocita, enterohromafino podobnih ćelija, i neurona. Njegova dejstva su posredovana histaminskim receptorima H1, H2, H3 i H4. Histaminski receptor H2 pripada rodopsinu sličnoj familiji G protein spregnutih receptora. On je integralni membranski protein koji stimuliše sekreciju želudačne kiseline. On takođe reguliše gastrointestinalnu motilnost i intestinalnu sekreciju. Smatra se da učestvuje u regulaciji ćelijskog rasta i diferencijacije.[1]

Tkivna distribucija[uredi - уреди]

Reference[uredi - уреди]

Literatura[uredi - уреди]

  • Hill SJ, Ganellin CR, Timmerman H et al. (1997). "International Union of Pharmacology. XIII. Classification of histamine receptors". Pharmacol. Rev. 49 (3): 253–78. PMID 9311023. 
  • Del Valle J, Gantz I (1997). "Novel insights into histamine H2 receptor biology". Am. J. Physiol. 273 (5 Pt 1): G987–96. PMID 9374694. 
  • Gantz I, Munzert G, Tashiro T et al. (1991). "Molecular cloning of the human histamine H2 receptor". Biochem. Biophys. Res. Commun. 178 (3): 1386–92. doi:10.1016/0006-291X(91)91047-G. PMID 1714721. 
  • Vannier E, Dinarello CA (1994). "Histamine enhances interleukin (IL)-1-induced IL-6 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells". J. Biol. Chem. 269 (13): 9952–6. PMID 7511596. 
  • Smit MJ, Timmerman H, Alewijnse AE et al. (1995). "Visualization of agonist-induced internalization of histamine H2 receptors". Biochem. Biophys. Res. Commun. 214 (3): 1138–45. doi:10.1006/bbrc.1995.2404. PMID 7575521. 
  • Nishi T, Koike T, Oka T et al. (1995). "Identification of the promoter region of the human histamine H2-receptor gene". Biochem. Biophys. Res. Commun. 210 (2): 616–23. doi:10.1006/bbrc.1995.1703. PMID 7755641. 
  • Traiffort E, Vizuete ML, Tardivel-Lacombe J et al. (1995). "The guinea pig histamine H2 receptor: gene cloning, tissue expression and chromosomal localization of its human counterpart". Biochem. Biophys. Res. Commun. 211 (2): 570–7. doi:10.1006/bbrc.1995.1851. PMID 7794271. 
  • Orange PR, Heath PR, Wright SR, Pearson RC (1996). "Allelic variations of the human histamine H2 receptor gene". Neuroreport 7 (7): 1293–6. doi:10.1097/00001756-199605170-00015. PMID 8817552. 
  • Elenkov IJ, Webster E, Papanicolaou DA et al. (1998). "Histamine potently suppresses human IL-12 and stimulates IL-10 production via H2 receptors". J. Immunol. 161 (5): 2586–93. PMID 9725260. 
  • Murakami H, Sun-Wada GH, Matsumoto M et al. (1999). "Human histamine H2 receptor gene: multiple transcription initiation and tissue-specific expression". FEBS Lett. 451 (3): 327–31. doi:10.1016/S0014-5793(99)00618-3. PMID 10371214. 
  • Wang LD, Wang M, Todisco A et al. (2000). "The human histamine H(2) receptor regulates c-jun and c-fos in a differential manner". Am. J. Physiol., Cell Physiol. 278 (6): C1246–55. PMID 10837353. 
  • Suh BC, Lee H, Jun DJ et al. (2001). "Inhibition of H2 histamine receptor-mediated cation channel opening by protein kinase C in human promyelocytic cells". J. Immunol. 167 (3): 1663–71. PMID 11466390. 
  • Brew OB, Sullivan MH (2002). "Localisation of mRNAs for diamine oxidase and histamine receptors H1 and H2, at the feto-maternal interface of human pregnancy". Inflamm. Res. 50 (9): 449–52. doi:10.1007/PL00000269. PMID 11603849. 
  • Shayo C, Fernandez N, Legnazzi BL et al. (2001). "Histamine H2 receptor desensitization: involvement of a select array of G protein-coupled receptor kinases". Mol. Pharmacol. 60 (5): 1049–56. PMID 11641433. 
  • Tanimoto A, Murata Y, Nomaguchi M et al. (2001). "Histamine increases the expression of LOX-1 via H2 receptor in human monocytic THP-1 cells". FEBS Lett. 508 (3): 345–9. doi:10.1016/S0014-5793(01)03073-3. PMID 11728449. 
  • Gutzmer R, Langer K, Lisewski M et al. (2002). "Expression and function of histamine receptors 1 and 2 on human monocyte-derived dendritic cells". J. Allergy Clin. Immunol. 109 (3): 524–31. doi:10.1067/mai.2002.121944. PMID 11898002. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Esbenshade TA, Kang CH, Krueger KM et al. (2003). "Differential activation of dual signaling responses by human H1 and H2 histamine receptors". J. Recept. Signal Transduct. Res. 23 (1): 17–31. doi:10.1081/RRS-120018758. PMID 12680587. 

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