Klobenpropit

Izvor: Wikipedia
Klobenpropit
(IUPAC) ime
N'-[(4-hlorofenil)metil]-1-[3-(3H-imidazol-4-il)propilsulfanil]formamidin
Klinički podaci
Identifikatori
CAS broj 145231-45-4
ATC kod nije dodeljen
PubChem[1][2] 2790
ChemSpider[3] 2688
ChEMBL[4] CHEMBL14690
Hemijski podaci
Formula C14H17ClN4S 
Mol. masa 308,83 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

Klobenpropit je histaminski antagonist H3 receptora.[5] On ima neuroprotektivno dejstvo, koje ostvaruje putem stimulacije otpuštanja gama-aminobuterne kiseline u mozgu.[6]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  5. Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). "The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes". Eur. J. Pharmacol. 567 (3): 206–10. doi:10.1016/j.ejphar.2007.04.032. PMID 17537431. 
  6. Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. European Journal of Pharmacology. 2007 Jun 1;563(1-3):117-23. PMID 17350613

Vidi još[uredi - уреди]

Spoljašnje veze[uredi - уреди]