Melanin-koncentrirajući hormonski receptor 2

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Melanin-koncentrirajući hormonski receptor 2
Identifikatori
Simboli MCHR2; MCH2; GPR145; MCH2R; SLT
Vanjski ID OMIM606111 HomoloGene50004 IUPHAR: MCH2 GeneCards: MCHR2 Gene
Ortolozi
Vrsta Čovek Miš
Entrez 84539 n/a
Ensembl ENSG00000152034 n/a
UniProt Q969V1 n/a
RefSeq (mRNA) NM_001040179 n/a
RefSeq (protein) NP_001035269 n/a
Lokacija (UCSC) Chr 6:
100.47 - 100.55 Mb
n/a
PubMed pretraga [1] n/a

Melanin-koncentrirajući hormonski receptor 2, takođe poznat kao MCH2, je ljudski gen, i receptor.[1] MCH2 je nađen kod ljudi, pasa, feretki, i nekih drugih primata i mesojeda, ali nije nađen kod miševa i pacova. Ovo je usporilo istraživanja na upotrebi ovog receptora kao terapeutske mete, pošto se većina ranih farmaceutskih istraživanja obično izvodi na malim sisarima kao što su miševi, pacovi, ili zečevi.


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Literatura[uredi - уреди]

Dodatna literatura[uredi - уреди]

  • Hill J, Duckworth M, Murdock P, et al. (2001). "Molecular cloning and functional characterization of MCH2, a novel human MCH receptor.". J. Biol. Chem. 276 (23): 20125–9. DOI:10.1074/jbc.M102068200. PMID 11274220. 
  • Mori M, Harada M, Terao Y, et al. (2001). "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor.". Biochem. Biophys. Res. Commun. 283 (5): 1013–8. DOI:10.1006/bbrc.2001.4893. PMID 11355873. 
  • Sailer AW, Sano H, Zeng Z, et al. (2001). "Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7564–9. DOI:10.1073/pnas.121170598. PMID 11404457. 
  • An S, Cutler G, Zhao JJ, et al. (2001). "Identification and characterization of a melanin-concentrating hormone receptor.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7576–81. DOI:10.1073/pnas.131200698. PMID 11416225. 
  • Wang S, Behan J, O'Neill K, et al. (2001). "Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2.". J. Biol. Chem. 276 (37): 34664–70. DOI:10.1074/jbc.M102601200. PMID 11459838. 
  • Bednarek MA, Feighner SD, Hreniuk DL, et al. (2001). "Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2.". Biochemistry 40 (31): 9379–86. DOI:10.1021/bi010867p. PMID 11478907. 
  • Bednarek MA, Tan C, Hreniuk DL, et al. (2002). "Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.". J. Biol. Chem. 277 (16): 13821–6. DOI:10.1074/jbc.M200563200. PMID 11839762. 
  • Audinot V, Lahaye C, Suply T, et al. (2002). "SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor.". Biochem. Biophys. Res. Commun. 295 (4): 841–8. DOI:10.1016/S0006-291X(02)00763-5. PMID 12127971. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMID 12477932. 
  • Logan DW, Bryson-Richardson RJ, Pagán KE, et al. (2003). "The structure and evolution of the melanocortin and MCH receptors in fish and mammals.". Genomics 81 (2): 184–91. DOI:10.1016/S0888-7543(02)00037-X. PMID 12620396. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. DOI:10.1038/nature02055. PMID 14574404. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
  • Vitale RM, Pedone C, De Benedetti PG, Fanelli F (2004). "Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations.". Proteins 56 (3): 430–48. DOI:10.1002/prot.20125. PMID 15229878. 
  • Hawes BE, Green B, O'Neill K, et al. (2004). "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.". Obes. Res. 12 (8): 1327–34. DOI:10.1038/oby.2004.167. PMID 15340116. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMID 15489334. 
  • "Melanin-Concentrating Hormone Receptors: MCH2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2999.