Praktolol
(Preusmjereno sa stranice Practolol)
| |||
| (IUPAC) ime | |||
|---|---|---|---|
| (RS)-N- {4-[2-hidroksi-3-(izopropilamino)propoksi]fenil}acetamid | |||
| Klinički podaci | |||
| Identifikatori | |||
| CAS broj | 6673-35-4 | ||
| ATC kod | C07AB01 | ||
| PubChem[1][2] | 4883 | ||
| DrugBank | DB01297 | ||
| ChemSpider[3] | 4715 | ||
| UNII | SUG9176GRW 
| ||
| KEGG[4] | D05587
| ||
| ChEBI | CHEBI:258351
| ||
| ChEMBL[5] | CHEMBL6995
| ||
| Hemijski podaci | |||
| Formula | C14H22N2O3 | ||
| Mol. masa | 266,336 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
Practolol (Eraldin, Dalzic, Praktol, Cardiol, Pralon, Cordialina, Eraldina, Teranol) selektivni je beta blokator koji je korišten u lečenju srčanih aritmija. Praktolol nije više u upotrebi jer je veoma toksičan uprkos toga što je hemijski veoma sličan sa propanololom.[6]
Nuspojave[uredi | uredi kod]
Nuspojave ovog leka su tipične za beta blokatore: bronhokonstrikcija, zatajenje srca, zamor, depresija i hipoglikemija.[7]
Zabrana[uredi | uredi kod]
Praktolol je zabranjen u Indiji.[8]
Reference[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ British Medical Journal, March 15, 1975
- ↑ Rod Flower; Humphrey P. Rang; Maureen M. Dale; Ritter, James M. (2007). Rang & Dale's pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-06911-5.
- ↑ „Drugs banned in India”. Central Drugs Standard Control Organization, Dte.GHS, Ministry of Health and Family Welfare, Government of India. Arhivirano iz originala na datum 2015-02-21. Pristupljeno 17. 9. 2013.
Литература[uredi | uredi kod]
- Rod Flower; Humphrey P. Rang; Maureen M. Dale; Ritter, James M. (2007). Rang & Dale's pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-06911-5.
