Angiotenzin

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Angiotenzin (inhibitor seprin peptidaze, klasa A, član 8)

Modeli angiotenzina I (levo) i II (desno) iz PDB 1N9U i PDB 1N9V.
Identifikatori
Simboli AGT; ANHU; SERPINA8
Vanjski ID OMIM106150 MGI87963 HomoloGene14 GeneCards: AGT Gene
Pregled RNK izražavanja
PBB GE AGT 202834 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 183 11606
Ensembl ENSG00000135744 ENSMUSG00000031980
UniProt P01019 Q3UTR7
Ref. Sekv. (iRNK) NM_000029 NM_007428
Ref. Sekv. (protein) NP_000020 NP_031454
Lokacija (UCSC) Chr 1:
228.9 - 228.92 Mb
Chr 8:
127.44 - 127.46 Mb
PubMed pretraga [1] [2]

Angiotenzin je protein koji se pod uticajem enzima renina daje angiotenzin I, čije se proteinsko tijelo sastoji od 10 aminokiselina.[1]

Angiotenzin se proizvodi u jetri, a cirkuliše u krvnoj plazmi čovjeka. On je bitan faktor kod regulacije krvnog pritiska, jer je direktni činilac sistema renin-angiotenzin-aldosteron (RAAS).[2]

Kod čovjeka, angiotenzin se sastoji iz 485 aminokiselina. NJegov gen leži na dugom kraku hromozoma 1.

Reference[uredi - уреди]

  1. Donald Voet, Judith G. Voet (2005). Biochemistry (3 izd.). Wiley. ISBN 978-0-471-19350-0. http://www.chem.upenn.edu/chem/research/faculty.php?browse=V. 
  2. Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell. New York: Garlard Science. ISBN 0-8153-3218-1. http://www.garlandscience.com/textbooks/0815332181.asp. 

Literatura[uredi - уреди]

  • de Gasparo M, Catt KJ, Inagami T, "et al." (2000). "International union of pharmacology. XXIII. The angiotensin II receptors". Parmacol Rev. 52 (3): 415–472. PMID 10977869. 
  • Brenner & Rector's The Kidney, 7th ed., Saunders, 2004.
  • Mosby's Medical Dictionary, 3rd Ed., CV Mosby Company, 1990.
  • Review of Medical Physiology, 20th Ed., William F. Ganong, McGraw-Hill, 2001.
  • Clinical Physiology of Acid-Base and Electrolyte Disorders, 5th ed., Burton David Rose & Theodore W. Post McGraw-Hill, 2001
  • Lees KR, MacFadyen RJ, Doig JK, Reid JL (1993). "Role of angiotensin in the extravascular system". Journal of human hypertension. 7 Suppl 2: S7–12. PMID 8230088. 
  • Weir MR, Dzau VJ (2000). "The renin-angiotensin-aldosterone system: a specific target for hypertension management". Am. J. Hypertens. 12 (12 Pt 3): 205S–213S. doi:10.1016/S0895-7061(99)00103-X. PMID 10619573. 
  • Berry C, Touyz R, Dominiczak AF, et al. (2002). "Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide". Am. J. Physiol. Heart Circ. Physiol. 281 (6): H2337–65. PMID 11709400. 
  • Sernia C (2002). "A critical appraisal of the intrinsic pancreatic angiotensin-generating system". JOP 2 (1): 50–5. PMID 11862023. 
  • Varagic J, Frohlich ED (2003). "Local cardiac renin-angiotensin system: hypertension and cardiac failure". J. Mol. Cell. Cardiol. 34 (11): 1435–42. doi:10.1006/jmcc.2002.2075. PMID 12431442. 
  • Wolf G (2006). "Role of reactive oxygen species in angiotensin II-mediated renal growth, differentiation, and apoptosis". Antioxid. Redox Signal. 7 (9-10): 1337–45. doi:10.1089/ars.2005.7.1337. PMID 16115039. 
  • Cazaubon S, Deshayes F, Couraud PO, Nahmias C (2006). "[Endothelin-1, angiotensin II and cancer]". Med Sci (Paris) 22 (4): 416–22. PMID 16597412. 
  • Ariza AC, Bobadilla NA, Halhali A (2007). "[Endothelin 1 and angiotensin II in preeeclampsia]". Rev. Invest. Clin. 59 (1): 48–56. PMID 17569300. 

Spoljašnje veze[uredi - уреди]


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