Bombezin

Izvor: Wikipedia
Bombezin
Bombesin full.png
Drugi nazivi Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
Identifikacija
CAS registarski broj 31362-50-2
PubChem[1][2] 16133891
IUPHAR ligand 616
Svojstva
Molekulska formula C71H110N24O18S
Molarna masa 1619.85



Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Bombezin je peptid sa 14-aminokiselina[3], koji je originalno izolovan iz kože žabe. On ima dva poznata homologa kod sisara koji se nazivaju neuromedin B i peptid oslobađanja gastrina.

Bombezin stimuliše oslobađanje gastrina i G ćelija. On aktivira tri različita G protein spregnuta receptora, koji su poznati kao BBR1 2 & 3.[4] On takođe aktivira te receptore u mozgu. Zajedno sa holecistokininom, on je drugi najveći izvor negativnog povratnog signala koji zaustavlja traženje hrane.[5]

Bombezin je takođe marker tumora za rak malih ćelija pluća, gastričnog karcinoma, i neuroblastoma.[6]

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Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gonzalez N, Moody TW, Igarashi H, Ito T, Jensen RT (February 2008). "Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states". Current Opinion in Endocrinology, Diabetes, and Obesity 15 (1): 58–64. doi:10.1097/MED.0b013e3282f3709b. PMC 2631407. PMID 18185064. 
  4. Weber HC (February 2009). "Regulation and signaling of human bombezin receptors and their biological effects". Current Opinion in Endocrinology, Diabetes, and Obesity 16 (1): 66–71. PMID 19115523. 
  5. Yamada K, Wada E, Wada K (November 2000). "Bombesin-like peptides: studies on food intake and social behaviour with receptor knock-out mice". Annals of Medicine 32 (8): 519–29. PMID 11127929. 
  6. Ohlsson B, Fredäng N, Axelson J (December 1999). "The effect of bombesin, cholecystokinin, gastrin, and their antagonists on proliferation of pancreatic cancer cell lines". Scandinavian Journal of Gastroenterology 34 (12): 1224–9. PMID 10636070. 

Spoljašnje veze[uredi - уреди]