RU-24,969

RU-24,969
(IUPAC) ime
	5-Metoksi-3-(1,2,5,6-tetrahidro-4-piridinil)-1H-indol
Klinički podaci
Identifikatori
CAS broj	107008-28-6
ATC kod	nije dodeljen
PubChem	108029
Hemijski podaci
Formula	C14H16N2O
Mol. masa	228,289 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3 ; Key: KRVMLPUDAOWOGN-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

RU-24,969 je lek i istraživačka hemikalija. On je selektivan agonist 5-HT_1A i 5-HT_1B receptora.^[3] Kao i kod drugih 5-HT_1B agonista, kao što je CP-94,253, za RU-24,969 je nađeno da pojačava dejstvo kokaina, što sugestira da 5-HT_1B receptori učestvuju u kokainskoj adikciji.^[4]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Doods HN, Kalkman HO, De Jonge A, Thoolen MJ, Wilffert B, Timmermans PB, Van Zwieten PA. (1985). „Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity.”. Eur J Pharmacol. 112 (3): 363–370. DOI:10.1016/0014-2999(85)90782-4. PMID 3160596.
↑ Parsons LH, Weiss F, Koob GF (December 1998). „Serotonin1B receptor stimulation enhances cocaine reinforcement”. Journal of Neuroscience 18 (23): 10078–89. PMID 9822762.

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