SB-204,741

Izvor: Wikipedia
SB-204,741
(IUPAC) ime
N-(1-Metil-1H-indol-5-il)-N'-(3-metilizotiazol-5-il)ureja
Klinički podaci
Identifikatori
CAS broj 152239-46-8
ATC kod nije dodeljen
PubChem[1][2] 3277600
Hemijski podaci
Formula C14H14N4OS 
Mol. masa 286,352 g/mol
SMILES eMolekuli & PubHem
Sinonimi SB-204,741
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

SB-204,741 je lek koji deluje kao potentan i selektivan antagonist na serotoninskom 5-HT2B receptoru, sa oko 135x selektivnošću u odnosu na blisko srodni 5-HT2C receptor, i još većom u odnosu na 5-HT2A receptor.[3] On se koristi u naučnim istraživanjima za ispitivanje funkcije 5-HT2B receptora.[4][5][6][7]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Forbes, IT; Jones, GE; Murphy, OE; Holland, V; Baxter, GS (1995). "N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT2B receptor antagonist". Journal of Medical Chemistry 38 (6): 855–7. doi:10.1021/jm00006a001. PMID 7699699. 
  4. Glusa, E; Pertz, HH (2000). "Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT2B receptors". British Journal of Pharmacology 130 (3): 692–8. doi:10.1038/sj.bjp.0703341. PMC 1572101. PMID 10821800. 
  5. Holohean, AM; Hackman, JC (2004). "Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones". British Journal of Pharmacology 143 (3): 351–60. doi:10.1038/sj.bjp.0705935. PMC 1575347. PMID 15339859. 
  6. Papageorgiou, A; Denef, C (2007). "Stimulation of growth hormone release by 5-hydroxytryptamine (5-HT) in cultured rat anterior pituitary cell aggregates: evidence for mediation by 5-HT2B, 5-HT7, 5-HT1B, and ketanserin-sensitive receptors". Endocrinology 148 (9): 4509–22. doi:10.1210/en.2007-0034. PMID 17584957. 
  7. Wouters, MM; Gibbons, SJ; Roeder, JL; Distad, M; Ou, Y; Strege, PR; Szurszewski, JH; Farrugia, G (2007). "Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors". Gastroenterology 133 (3): 897–906. doi:10.1053/j.gastro.2007.06.017. PMID 17854596. 

Spoljašnje veze[uredi - уреди]