SDZ SER-082

Izvor: Wikipedia
SDZ SER-082
(IUPAC) ime
(+)-cis 4,5,7a,8,9,10,11,11a-oktahidro-7H-10-metilindolo[1,7-bc][2,6]-naftiridin
Klinički podaci
Identifikatori
CAS broj 141474-54-6
ATC kod nije dodeljen
PubChem[1][2] 9859407
Hemijski podaci
Formula C15H20N2 
Mol. masa 228,332 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

SDZ SER-082 je lek koji deluje kao mešoviti antagonist za 5-HT2B i 5-HT2C serotoninske receptore, sa dobrom selektivnošću za druge tipove serotoninskog receptora i malom preferencijom za 5-HT2C u odnosu na 5-HT2B.[3] On je korišten u životinjskim studijama uticaja dejstva različitih 5-HT2 podtipova,[4][5][6] i kako oni utiču na efekte drugih lekova poput kokaina.[7][8][9]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Nozulak J, Kalkman HO, Floerscheim P, Hoyer D, Schoeffter P, Buerki HR. (+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]- naphthyridine: A 5-HT2C/2B Receptor Antagonist with Low 5-HT2A Receptor Affinity. Journal of Medicinal Chemistry. 1995 Jan;38(1):28-33. DOI:10.1021/jm00001a007
  4. Mora PO, Netto CF, Graeff FG (December 1997). "Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze". Pharmacology, Biochemistry, and Behavior 58 (4): 1051–7. doi:10.1016/S0091-3057(97)00057-9. PMID 9408213. 
  5. Dave KD, Harvey JA, Aloyo VJ (May 2002). "A novel behavioral model that discriminates between 5-HT2A and 5-HT2C receptor activation". Pharmacology, Biochemistry, and Behavior 72 (1-2): 371–8. doi:10.1016/S0091-3057(01)00767-5. PMID 11900808. 
  6. Hawkins MF, Uzelac SM, Hearn JK, Baumeister AA (October 2008). "Effects of selective serotonin2 ligands on behaviors evoked by stress in the rat". Pharmacology, Biochemistry, and Behavior 90 (4): 632–9. doi:10.1016/j.pbb.2008.05.006. PMID 18572227. 
  7. Filip M, Bubar MJ, Cunningham KA (September 2004). "Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses". The Journal of Pharmacology and Experimental Therapeutics 310 (3): 1246–54. doi:10.1124/jpet.104.068841. PMID 15131246. 
  8. Filip M (2005). "Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats". Pharmacological Reports : PR 57 (1): 35–46. PMID 15849375. 
  9. Filip M, Bubar MJ, Cunningham KA (January 2006). "Contribution of serotonin (5-HT) 5-HT2 receptor subtypes to the discriminative stimulus effects of cocaine in rats". Psychopharmacology 183 (4): 482–9. doi:10.1007/s00213-005-0197-y. PMID 16261316. 

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