25I-NBOH
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| |||
| (IUPAC) ime | |||
|---|---|---|---|
| 2-((2-(4-jodo-2,5-dimetoksifenil)etilamino)metil)fenol | |||
| Klinički podaci | |||
| Identifikatori | |||
| CAS broj | 919797-20-9 | ||
| ATC kod | nije dodeljen | ||
| PubChem[1][2] | 10001761 | ||
| ChemSpider[3] | 8177342 | ||
| Hemijski podaci | |||
| Formula | C17H20INO3 | ||
| Mol. masa | 413,249 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
| |||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
25I-NBOH (NBOH-2CI, Cimbi-27) je fenetilaminski halucinogen. On deluje kao potentan agonist 5HT2A receptora,[4][5] sa Ki od 0,061 nM na ljudskom 5HT2A receptoru, te je dvanaest puta potentniji od liganda 2C-I. In vitro testovi su pokazali da ovo jedinjenje deluje kao agonist, ali rezultati životinjskih studija nisu objavljeni. Dok su N-benzilni derivati 2C-I liganda znatno povećavali potentnost, N-benzil derivati 2,5-dimetoksi-4-jodoamfetamina su neaktivni.[6]
Reference[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Ettrup, A. et al. (2010). „Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers”. European Journal of Nuclear Medicine and Molecular Imaging 38 (4): 681–693. DOI:10.1007/s00259-010-1686-8. ISBN 0025901016868. PMID 21174090.
- ↑ Silva ME, Heim R, Strasser A, Elz S, Dove S (January 2011). „Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor”. Journal of Computer-aided Molecular Design 25 (1): 51–66. DOI:10.1007/s10822-010-9400-2. PMID 21088982.
- ↑ Braden, MR; Parrish, JC; Naylor, JC; Nichols, DE (2006). „Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists”. Molecular Pharmacology 70 (6): 1956–64. DOI:10.1124/mol.106.028720. PMID 17000863.
Vidi još[uredi | uredi kod]
- 2CBCB-NBOMe (NBOMe-TCB-2)
- 2CBFly-NBOMe (NBOMe-2CB-Fly)
- 25B-NBOMe (NBOMe-2CB)
- 2C-C-NBOMe (NBOMe-2CC)
- 25I-NBMD (NBMD-2CI)
- 25I-NBOMe (NBOMe-2CI)
- 2C-TFM-NBOMe (NBOMe-2C-TFM)
- 25I-NBF (NBF-2CI)
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