PNU-22394

Izvor: Wikipedia
PNU-22394
(IUPAC) ime
6-Metil-1,2,3,4,5,6-heksahidro-azepino[4,5-b]indol
Klinički podaci
Identifikatori
CAS broj 15923-78-1
ATC kod nije dodeljen
PubChem[1][2] 27559
ChEMBL[3] CHEMBL6557
Hemijski podaci
Formula C13H16N2 
Mol. masa 200,279 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

PNU-22394 je lek koji deluje kao agonist na serotoninskim 5-HT2 receptorima, sa većim afinitetom vezivanja za 5-HT2A i 5-HT2C i nešto manjim za 5-HT2B, mada je on pun agonist 5-HT2C, a parcijalni agonist za 5-HT2A i 5-HT2B. On proizvodi anoreksične efekte kod životinja i ljudi. Ovaj lek nije razvijen meri neophodnoj za medicinsku upotrebu.[4][5]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  4. McCall RB, Franklin SR, Hyslop DK, Knauer CS, Chio CL, Haber CL, Fitzgerald LW. PNU-22394, a 5-HT2C receptor agonist, reduced feeding in rodents and produces weight loss in humans. Soc Neurosci Abstr. 2001;27,309.302.
  5. Garfield AS, Heisler LK (January 2009). "Pharmacological targeting of the serotonergic system for the treatment of obesity". The Journal of Physiology 587 (Pt 1): 49–60. doi:10.1113/jphysiol.2008.164152. PMC 2670022. PMID 19029184. 

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