PNU-22394

PNU-22394
(IUPAC) ime
	6-Metil-1,2,3,4,5,6-heksahidro-azepino[4,5-b]indol
Klinički podaci
Identifikatori
CAS broj	15923-78-1
ATC kod	nije dodeljen
PubChem	27559
ChEMBL	CHEMBL6557
Hemijski podaci
Formula	C13H16N2
Mol. masa	200,279 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C13H16N2/c1-15-12-5-3-2-4-10(12)11-6-8-14-9-7-13(11)15/h2-5,14H,6-9H2,1H3 ; Key: ZBXDOQWPGBISAR-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

PNU-22394 je lek koji deluje kao agonist na serotoninskim 5-HT₂ receptorima, sa većim afinitetom vezivanja za 5-HT_2A i 5-HT_2C i nešto manjim za 5-HT_2B, mada je on pun agonist 5-HT_2C, a parcijalni agonist za 5-HT_2A i 5-HT_2B. On proizvodi anoreksične efekte kod životinja i ljudi. Ovaj lek nije razvijen meri neophodnoj za medicinsku upotrebu.^[4]^[5]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ McCall RB, Franklin SR, Hyslop DK, Knauer CS, Chio CL, Haber CL, Fitzgerald LW. PNU-22394, a 5-HT2C receptor agonist, reduced feeding in rodents and produces weight loss in humans. Soc Neurosci Abstr. 2001;27,309.302.
↑ Garfield AS, Heisler LK (January 2009). „Pharmacological targeting of the serotonergic system for the treatment of obesity”. The Journal of Physiology 587 (Pt 1): 49–60. DOI:10.1113/jphysiol.2008.164152. PMC 2670022. PMID 19029184.

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[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[4] McCall RB, Franklin SR, Hyslop DK, Knauer CS, Chio CL, Haber CL, Fitzgerald LW. PNU-22394, a 5-HT2C receptor agonist, reduced feeding in rodents and produces weight loss in humans. Soc Neurosci Abstr. 2001;27,309.302.

[pmid19029184-5] Garfield AS, Heisler LK (January 2009). „Pharmacological targeting of the serotonergic system for the treatment of obesity”. The Journal of Physiology 587 (Pt 1): 49–60. DOI:10.1113/jphysiol.2008.164152. PMC 2670022. PMID 19029184.

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PNU-22394

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