Ksilamidin

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Ksilamidin
(IUPAC) ime
N'-[2-(3-methoxyphenoxy)propyl]-2-(3-methylphenyl)ethanimidamide
Klinički podaci
Identifikatori
CAS broj 6443-50-1
ATC kod nije dodeljen
PubChem[1][2] 22951
Hemijski podaci
Formula C19H24N2O2 
Mol. masa 312.406 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status

Ksilamidin je lek koji deluje kao antagonist 5HT2A receptora, i u manjoj meri 5HT1A receptora. On ne prelazi krvno moždanu barijeru iz kog razloga je koristan za blokiranje perifernih serotonergijskih responsa poput kardiovaskularnog[3][4] i gastrointestinalnog dejstva,[5] bez proizvođenja centralnih efekata 5HT2A blokade kao što je sedacija, ili ometanja centralno delujućih 5HT2A agonista.[6]

Literatura[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Fuller, RW; Kurz, KD; Mason, NR; Cohen, ML (1986). "Antagonism of a peripheral vascular but not an apparently central serotonergic response by xylamidine and BW 501C67". European journal of pharmacology 125 (1): 71–7. PMID 3732393. 
  4. Dedeoğlu, A; Fisher, LA (1991). "Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms". The Journal of pharmacology and experimental therapeutics 259 (3): 1027–34. PMID 1762059. 
  5. Baker, BJ; Duggan, JP; Barber, DJ; Booth, DA (1988). "Effects of dl-fenfluramine and xylamidine on gastric emptying of maintenance diet in freely feeding rats". European journal of pharmacology 150 (1-2): 137–42. PMID 3402534. 
  6. Dave, KD; Quinn, JL; Harvey, JA; Aloyo, VJ (2004). "Role of central 5-HT2 receptors in mediating head bobs and body shakes in the rabbit". Pharmacology, biochemistry, and behavior 77 (3): 623–9. doi:10.1016/j.pbb.2003.12.017. PMID 15006475. 

Spoljašnje veze[uredi - уреди]


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