Lesopitron

Izvor: Wikipedia
Lesopitron
(IUPAC) ime
24-[4-(4-hloro-1H-pirazol-1-il)butil]piperazin-1-il}pirimidin
Klinički podaci
Identifikatori
CAS broj 132449-46-8
ATC kod nije dodeljen
PubChem[1][2] 60813
ChemSpider[3] 54801
UNII H1CGM4755H YesY
Hemijski podaci
Formula C15H21ClN6 
Mol. masa 320,82 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća  ?
Pravni status Nije kontrolisana supstanca
Način primene Oralno

Lesopitron (E-4424) je selektivni pun agonist 5-HT1A receptora koji je strukturno srodan sa azapironima.[4] On je bio u razvoju kao anksiolitik za tretman generalizovanog anksioznog poremećaja.[5][6] Dospeo je do faze II kliničkih ispitivanja, ali je razvoj prekinut.[5][6]

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Haj-Dahmane S, Jolas T, Laporte AM, et al. (April 1994). "Interactions of lesopitron (E-4424) with central 5-HT1A receptors: in vitro and in vivo studies in the rat". European Journal of Pharmacology 255 (1-3): 185–96. doi:10.1016/0014-2999(94)90097-3. PMID 8026543. 
  5. 5.0 5.1 Micheli F (February 2001). "Lesopitron (Esteve)". IDrugs : the Investigational Drugs Journal 4 (2): 218–24. PMID 16032484. 
  6. 6.0 6.1 Fresquet A, Sust M, Lloret A, et al. (February 2000). "Efficacy and safety of lesopitron in outpatients with generalized anxiety disorder". The Annals of Pharmacotherapy 34 (2): 147–53. PMID 10676820. 

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